What Is The Main Cause Of Vascular Dementia – Vascular dementia is a general term that describes problems with intelligence, planning, judgment, memory, and other thought processes caused by brain damage from impaired blood flow to your brain.

You can develop vascular dementia after a stroke blocks an artery in your brain, but a stroke doesn’t always cause vascular dementia. Whether a stroke affects your thinking depends on the severity and location of your stroke. Vascular dementia can also be caused by other conditions that damage blood vessels and reduce circulation, depriving your brain of vital oxygen and nutrients.

What Is The Main Cause Of Vascular Dementia

Factors that increase your risk of heart disease and stroke — including diabetes, high blood pressure, high cholesterol and smoking — also increase your risk of vascular dementia. Controlling these factors may help reduce your chances of developing vascular dementia.

Vascular Dementia And Vascular Cognitive Impairment (chapter 15)

The symptoms of vascular dementia vary, depending on the part of your brain where blood flow is impaired. Symptoms often overlap with those of other types of dementia, particularly Alzheimer’s disease dementia. But unlike Alzheimer’s disease, the most important symptoms of vascular dementia are related to speed of thinking and problem solving rather than memory loss.

Symptoms of vascular dementia may be most obvious when they occur suddenly after a stroke. When the changes in your thinking and thinking seem clearly related to the stroke, this condition is sometimes called post-stroke dementia.

Sometimes a characteristic pattern of vascular dementia symptoms follows a series of strokes or smaller ones. The changes in your thought processes come in dramatic steps down from your previous level of functioning, as opposed to the slow, steady decline that usually occurs in Alzheimer’s disease dementia.

But vascular dementia can also develop very slowly, like Alzheimer’s disease dementia. In addition, vascular disease and Alzheimer’s disease often occur together.

All You Need To Know About Smoking And Dementia

Vascular dementia results from conditions that damage the blood vessels in your brain, reducing their ability to supply your brain with the amounts of nutrients and oxygen it needs to carry out thought processes effectively.

With both silent and overt strokes, the risk of vascular dementia increases with the number of strokes that occur over time. A type of vascular dementia that involves multiple strokes is called multi-infarct dementia.

In general, risk factors for vascular dementia are similar to those for heart disease and stroke. Risk factors for vascular dementia include: Prophylactic hydration of hydrogen-rich water reduces corneal inflammation and promotes wound healing by activating antioxidant activity in the Rat Alkaline Burn Model.

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The Four Most Common Types Of Dementia

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Why Dementia Causing Plaques Become Trapped In The Brain

By Liv Tybjærg Nordestgaard Liv Tybjærg Nordestgaard Scilit Preprints.org Google Scholar View Publication 1, * , Mette Christoffersen Mette Christoffersen Scilit Preprints.org Google Scholar View Publication 1 and Ruth Frikke-Schmidt Ruth Frikke-Schmidt Ruth Frikke-Schmidt , 2

Submitted: 27 July 2022 / Revised: 21 August 2022 / Approved: 24 August 2022 / Published: 29 August 2022

Alzheimer’s disease is the most common form of dementia, and the prodromal stages of Alzheimer’s disease can last for decades. Vascular dementia is the second most common form of dementia and is distinguished from Alzheimer’s disease by evidence of prior stroke or hemorrhage and current cerebrovascular disease. A combined group of vascular-related dementias (vascular dementia and dementia indeterminate) is often referred to as non-Alzheimer’s dementia. Recent evidence suggests that preventing dementia through lifestyle interventions early in life with a focus on reducing cardiovascular risk factors is a promising strategy for reducing future risk. About 40% of dementia cases are estimated to be preventable by targeting modifiable cardiovascular risk factors. The aim of this review is to describe the relationship between risk factors for atherosclerotic cardiovascular disease and the risk of Alzheimer’s disease and non-Alzheimer’s dementia by providing an overview of the current evidence and highlighting common pathogenic pathways between dementia and cardiovascular disease. mother. . Risk factors include body mass index (BMI); Plasma triglycerides-, high-density lipoprotein (HDL) cholesterol-, low-density lipoprotein (LDL) cholesterol-, and total cholesterol; hypertension; diabetes; non-alcoholic fatty liver disease (NAFLD); physical inactivity; smoking; diet gut microbiome; and genetics. In addition, we aimed to distinguish between risk factor associations in middle age compared to late age.

Dementia is a clinical diagnosis defined by cognitive symptoms that interfere with the ability to function in normal activities [1]. It is a devastating neurodegenerative disease that affects more than 50 million people worldwide [2]. The most common symptoms are problems with memory, language, problem solving, and other thinking skills [3], and are preceded by a period in which individuals have subtle cognitive changes called mild cognitive impairment (MCI) [3]. . The dementia syndrome is categorized as mild, moderate, or severe [3].

Brain Imaging In Differential Diagnosis Of Dementia

Alzheimer’s disease is the most common form of dementia, and the prodromal stages of Alzheimer’s disease can last for decades [4]. The disease is categorized as early-onset dementia (before age 65) and late-onset (after age 65) dementia [5]. It has been seen as a mysterious disease with no clear single cause, various hypotheses about its pathogenesis, and no curative treatment. Although β-amyloid is the pathological hallmark of Alzheimer’s disease, the amyloid cascade hypothesis that Alzheimer’s disease is mainly caused by the accumulation of toxic β-amyloid [ 6 ] has been repeatedly tested. Randomized clinical trials aimed at reducing the burden of β-amyloid have shown no effect on the end point of the disease [ 7 , 8 , 9 , 10 , 11 ], and β-amyloid plaques are visible in cognitively normal individuals [ 12] and people without dementia [13].

Vascular dementia is the second most common form of dementia and is differentiated from Alzheimer’s disease by evidence of previous stroke or hemorrhage and current cerebrovascular disease [ 3 ]. Other types of dementia include frontotemporal dementia [14], Lewy body dementia [15], unknown dementia [3], and mixed dementia [3]. Many types of dementia in the undiagnosed dementia category are likely to be vascular in origin, and therefore, undiagnosed dementia and vascular dementia are often categorized as non-Alzheimer’s dementia [ 16 , 17 ]. This classification will be used throughout the review.

Recent evidence suggests that treating or reversing Alzheimer’s disease in the prodromal stages or after the onset of the disease is futile. Conversely, disease prevention through lifestyle interventions early in life with a focus on reducing cardiovascular risk factors is a promising strategy to reduce the future risk of dementia [ 16 , 18 ]. One study estimated that approximately 40% of dementia cases worldwide could be prevented by targeting modifiable cardiovascular risk factors [2]. Furthermore, neuroimaging studies have suggested that early vascular dysfunction is the initial pathological event leading to late-onset Alzheimer’s disease [ 19 , 20 ].

The aim of this review was to describe the associations between risk factors for atherosclerotic cardiovascular disease, including body mass index (BMI); Plasma triglycerides-, high-density lipoprotein (HDL) cholesterol-, low-density lipoprotein (LDL) cholesterol-, and total cholesterol; hypertension; diabetes; non-alcoholic fatty liver disease (NAFLD); physical inactivity; smoking; diet gut microbiome; genetics; and risk of dementia. We aim to summarize the current evidence and shed light on shared pathogenic pathways between atherosclerotic cardiovascular disease and Alzheimer’s disease, non-Alzheimer’s dementia, and all-cause dementia. Furthermore, we aim to distinguish between risk factor associations in middle age compared to late age.

Causes Of Dementia

The general diagnostic criteria for dementia according to the International Classification of Diseases (ICD) version 10 are: (1) memory loss and other cognitive function impairment, (2) preserved consciousness sufficient to allow judgment of memory loss, (3) impairment emotional control, motivation, or social interaction, (4) duration of more than 6 months. In addition, the symptoms must not be explained by other major psychiatric disorders [3]. Dementia has many causes, and Alzheimer’s disease and vascular dementia are two of the most common. The diagnosis of both types of dementia is based on family and medical history, cognitive tests such as the Mini-Mental State Examination (MMSE), and a perception from close relatives about the patient’s changes in behavior, abilities and / or mood [3, 4]. .

Alzheimer’s disease was first described in 1907 by Alois Alzheimer [21]. Postmortem examination of the patient’s brain was described

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