What Can Cause High Protein In Urine – Screening for urine protein during pregnancy is part of your routine prenatal care (1). During pregnancy, urinary protein excretion doubles and can reach 300 mg/24 hours versus 150 mg/24 hours in non-pregnant women.

According to the American College of Obstetrics and Gynecology (ACOG), if urinary protein excretion exceeds 300 mg in 24 hours, protein/creatinine is present.

What Can Cause High Protein In Urine

XA muscle waste product removed from the kidneys through urine has a ratio of ≥0.3 mg/mg or gives 2+ or more readings on urine dipstick testing, this can be defined as proteinuria or high levels of protein in urine during pregnancy (2).

Proteinuria In Children

Read on to learn the causes of increased urinary protein excretion during pregnancy, its risk factors, symptoms, and how to treat it in a pregnant woman.

Some risk factors that may increase the likelihood of high protein in your urine during pregnancy include (6)(7):

You may not notice any symptoms of mildly elevated protein levels in your urine. However, high levels of protein in the urine during pregnancy can cause the following symptoms (8).

Additionally, since proteinuria is closely associated with preeclampsia in later stages of pregnancy, you should also look for symptoms of preeclampsia. These symptoms may include (9):

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Proteinuria is not a disorder, but a condition caused by various factors and diseases in pregnant women. However, you should carefully monitor the level of protein in your urine and do not neglect it.

If you have a slight increase in protein levels in your urine, simple diet and lifestyle changes may be helpful. Proteinuria with underlying medical conditions such as hypertension and infection will require treatment of the condition with medications to ultimately cure the proteinuria (8)(11). Your doctor may also suggest lifestyle changes, such as including exercise and avoiding certain foods, to reduce the level of protein in your urine.

Although proteinuria during pregnancy cannot be prevented, you can take the following measures to control its underlying causes and its further effects (3)(8).

Although protein in urine does not have any direct harmful effects on the baby, it is a likely sign of many adverse complications associated with pregnancy, such as preeclampsia, preterm birth, and fetal growth restriction, which can adversely affect the fetus (9).

Bence Jones Protein In Urine: Tests And Causes

Yes. Proteinuria or albuminuria can occur without preeclampsia due to other conditions such as renal dysfunction (impaired kidney function) and UTI infections (2).

No. Drinking water has nothing to do with urine protein levels. Drinking more water may temporarily dilute the protein in your urine but will not cure the condition (8).

Stress during pregnancy can cause protein levels in your urine to temporarily increase. Other factors that contribute to elevated protein levels include heavy exercise and poor diet (12).

Yes, dehydration or loss of water from the body can contribute to increased protein levels in the urine. Thus, staying hydrated during pregnancy is important to avoid obstetric complications.

Urine 24 Hour Volume

Urine contains some protein, but when protein levels increase, it results in proteinuria. Most cases usually occur due to physiological changes during pregnancy, but some may occur due to underlying problems, including serious medical conditions such as preeclampsia, kidney problems and diabetes. High levels of protein in the urine do not cause any problems for the fetus, but conditions that cause high levels of protein can have health complications for the mother. Therefore, timely treatment of the causes is important as it also reduces the level of protein in the urine. A healthy lifestyle and prenatal care are some ways to prevent high protein in your urine during pregnancy.

Although pregnancy can cause increased protein in the urine, it can also be caused by a more severe condition such as preeclampsia. Therefore, it is important to know the symptoms and diagnostic process to identify potential complications early. For more details, read the infographic below.

The articles are written after analyzing the research works of expert authors and institutions. Our links consist of resources created by authorities in their respective areas. You can find out more about the accuracy of the information we present in our editorial policy.

Dr. Irene (Eirini) Orphanoudaki is a gynecologist-obstetrician in private practice in Heraklion, Crete, and collaborates with the private medical clinic “MITERA” – Euromeda in Heraklion. With approximately 21 years of experience as a gynecologist-obstetrician, she specializes in Ultrasound, Colposcopy, Minimal and Advanced Gynecological Surgery, Aesthetic Gynecology, Infertility Consultation, Menopause Consultation, Surgical Obstetrics, High Risk Pregnancy, Normal Labor, Antenatal and Maternity period. , postpartum care, …more

Protein Loss In Urine (proteinuria)

Anisha holds a Bachelor’s degree in Biotechnology from USTM, Meghalaya and a Master’s degree in Applied Microbiology from VIT, Vellore. With two years of experience, she has worked on various research projects in the field of food science. She also has an internship experience with Oil India Limited as an R&D Project Trainee. As a writer at , Anisha guarantees…read more

Rebecca is a pregnancy writer and editor with a passion for providing research-based and engaging content in the areas of fertility, pregnancy, birth and postpartum. She graduated from Loyola Academy and Osmania University with a degree in Biotechnology and Genetics and received a certificate in Nutrition and Lifestyle during Pregnancy from the Ludwig Maximilian University of Munich (LMU). She deals with health and…read more

Reshmi Das has over four years of experience as a clinical coordinator, medical writer, and medical conference coordinator. Her constant interest in medical journals and writing drives her to write well-researched articles for . She writes health and wellness articles for children and pregnant and breastfeeding women. Reshmi completed her graduate studies in biotechnology at MITS School of Biotechnology. …moreThe main protein in your blood is called albumin. Proteins perform many important functions in the body, such as helping to build bones and muscles, preventing infections, and controlling the amount of fluid in the blood.

Each normal kidney has about a million functioning units called nephrons. Each nephron has a filtering unit called a glomerulus, in which the blood is filtered and the filtrate is formed. The nephron also has tubular parts called tubules that absorb and excrete urine components from the filtrate, ultimately producing urine that is excreted from the body. Protein in the urine, called proteinuria, is one of the important signs of kidney disease.

High Sugar In Urine: Diabetes, Pregnancy, And More

Healthy kidneys remove excess fluid and waste from food, but allow proteins and other important nutrients to pass through and return to the bloodstream. When the kidneys are working as they should, they may leave some proteins (albumin) outside their filters in the urine. When you have protein in your urine, it is called proteinuria (or albuminuria). The presence of protein in the urine may be a sign of nephrotic syndrome or early kidney disease.

Anyone can develop proteinuria. You may be at higher risk if you have one or more risk factors for kidney disease, such as:

If you take a normal kidney, then about 180 liters of filtrate are produced from plasma (the liquid component of blood) per day. The amount of plasma filtered to produce 180 liters of filtrate contains approximately 10 kg of protein. However, only 0.01% or 1 gram of protein passes into the glomerular filtrate. This occurs due to a “filtration barrier” within the glomerulus that limits the passage of large molecules such as albumin into the urine and allows water and small solvents to pass through. Due to the filtration barrier, only a small amount of albumin is excreted in the urine. Small molecules called low molecular weight proteins (LMWs) easily pass the filtration barrier and end up in the filtrate. The filtered load of these small molecules is smaller and is ultimately excreted from the body in even smaller quantities as the LMW proteins are reabsorbed again by the renal tubules. There are also small amounts of proteins in the urine that are not filtered but are directly secreted into the urine by the kidneys (for example, Tamm-Horsfall protein).

Proteins found in urine are divided into two main groups: plasma proteins (mainly albumin, although in small quantities) and proteins secreted from the renal tubules. In total, less than 150 mg of protein is excreted per day, of which less than 30 mg is excreted in urine per day.

The Ratio And Difference Of Urine Protein To Creatinine Ratio And Albumin To Creatinine Ratio Facilitate Risk Prediction Of All Cause Mortality

Proteinuria may occur in healthy young adults due to the upright position. This is called postural proteinuria, which is usually less than 1 gram per day. In this condition, protein is detected in a random urine sample, but no protein is detected in the first morning urine sample (after lying down at night). This condition is benign and does not indicate kidney disease. Normal people and people with chronic kidney disease (CKD) have daily fluctuations in protein excretion. At night, protein excretion is lower and less variable than during the day. Samples taken at the first void in the morning are more likely to accurately predict 24-hour protein and albumin excretion.

When you start having kidney problems and have little protein in your urine, you will not feel symptoms. The only way to know if you have protein in your urine is to take a urine test. A urine protein test measures the amount of albumin in the urine compared to the amount of creatinine.

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