Use Of Vitamin B12 In Human Body – Vitamin B12 plays an important role in many body functions. But the benefits of vitamin B12 are less talked about. Vitamin B12 deficiency is a serious problem in Central and South America, Mexico, the Indian subcontinent, and parts of Africa (1).

This vitamin significantly improves heart health, helps manage skin conditions, improves memory and helps improve mood. The daily intake of vitamin B12 for adults is 2.4 micrograms (2).

Use Of Vitamin B12 In Human Body

Find out what it says about vitamin B12 and the benefits it offers from the article below. Also see which foods are rich in this vitamin and what are the symptoms of its deficiency. Scroll down!

The Role Of The Gut In Vitamin B12 And Iron Deficiency (and What To Do About It)

Vitamin B12, also known as cobalamin, helps the body’s blood cells and nerves function properly. It also plays a role in DNA synthesis (3).

The vitamin is also known for preventing megaloblastic anemia, a type of anemia that makes people weak. Studies show that a deficiency of this nutrient can lead to the condition (4).

Vitamin B12 is absorbed in the body in two stages. In food, this vitamin is bound to proteins. Hydrochloric acid in the stomach separates vitamin B12 from this protein synthesis. The vitamin then combines with another protein produced by the stomach (called intrinsic factor). It is then absorbed into the body (5).

Individuals with pernicious anemia (a decrease in the number of red blood cells) may be deficient in vitamin B12 because their bodies are unable to produce intrinsic factor (3).

Vitamin B12: Benefits, Food Sources, And Side Effects

Vitamin B12 is important for various body functions. In the next section, we will discuss the most important benefits of vitamin B12 in detail.

Vitamin B12 (along with folate) helps make red blood cells. Without enough vitamin B12, red blood cells do not divide normally as they should and become too large. This makes it difficult for them to leave the bone marrow (6).

This can cause a decrease in red blood cells in the bloodstream to carry oxygen to the body, causing a feeling of fatigue and weakness. This condition is also called pernicious anemia, and if left untreated, it can damage the brain, heart, and other organs in the body (6).

Vitamin B12 is one of the most important components during pregnancy. Deficiency of this vitamin can lead to infertility and recurrent miscarriages (7).

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Starting a pregnancy with vitamin B12 deficiency may increase the risk of neural tube defects in the newborn. It can also cause premature birth. Maternal deficiency can also cause the same in the newborn if there is not enough vitamin B12 available in breast milk. However, these effects need more research (7).

Women with vitamin B12 levels below 300 ng/L have a higher risk of giving birth to babies with birth defects (8). Increasing B12 levels above this may reduce the risk, although more research is needed (8).

Vitamin B12 is needed to make new maternal and fetal cells and to prevent neural tube defects in the newborn (9). It works together with folate to achieve this. Vitamin B12 deficiency can also lead to folate deficiency, which negatively affects pregnancy.

The vitamin can treat nausea and morning sickness often associated with pregnancy. However, research in this aspect is limited.

Healthvit Vitamin B12 + D With Folic Acid

Vitamin B12 deficiency is associated with changes in the skin. The most common symptom is hyperpigmentation (10).

X An autoimmune disease that causes patchy loss of skin color due to melanin deficiency and also affects the mouth, hair and eyes. and other skin lesions

X Pathological changes in the appearance of the skin or tissues, usually caused by injury or disease. (11), (12).

Vitamin B12 can also help treat some serious skin conditions. One study found that vitamin B12 cream can reduce the extent and severity of eczema. This was especially true for eczema in children (13).

What Is Vitamin B12 Good For? Energy, Health Benefits Explained

The cream can be purchased at a pharmacy. Apply it on the affected areas twice a day. Be sure to consult your doctor. B12 also helps reduce inflammation and its side effects, which is one of the reasons it can prevent eczema.

Vitamin B12 can also help reduce the pain of shingles. Anecdotal evidence suggests that taking 1,000 micrograms of vitamin B12 daily may help treat this condition. However, since research is limited, we recommend that you consult your doctor before use.

XA condition where fat deposits under the skin cause lumpy flesh on the thighs, buttocks and abdomen. , but there is limited research to prove this.

Vitamin B12 deficiency was observed in those with hair loss (15). At the base of the hair follicles, we have tiny blood vessels that connect to the roots of each hair strand. These blood vessels deliver oxygen to the hair, thus promoting hair growth and preventing hair loss.

Intrinsic Factor Hi Res Stock Photography And Images

Vitamin B12 has shown potential for the prevention and treatment of heart disease. The nutrient lowered homocysteine ​​(a special amino acid), high levels of which can increase the risk of coronary heart disease (16).

A deficiency in B vitamins was generally associated with higher homocysteine ​​levels and an increased risk of stroke (16). It can also reduce long-term costs associated with expensive medical treatment.

Although there is no direct link between vitamin B12 and the treatment of diabetes, the nutrient may treat diabetic retinopathy (damage to the blood vessels in the eye) (18).

It may help treat diabetic neuropathy (nerve damage in the legs and feet), although further research is needed (19). Anecdotal evidence suggests that the vitamin may also treat some neuropathy symptoms, including numbness, pain, and tingling.

Liquid Vitamin B1, B6 & B12

Even more interestingly, metformin, which is commonly prescribed to treat diabetes, can cause vitamin B12 deficiency (21). So it might be a good idea to supplement it, especially in diabetes. Pernicious anemia is a vitamin B12 deficiency that occurs in type 1 diabetes (22).

Low plasma levels of vitamin B12 are associated with lower bone mineral density in humans. Studies show that the vitamin can affect bone formation. It is also associated with osteoblastic activity (bone formation) (23).

XA bone disease that causes bones to become weak and brittle due to low bone mineral density and reduced bone mass. (24). Because vitamin B12 helps lower homocysteine ​​levels, it may play a beneficial role.

In a study of older women, lower levels of vitamin B12 were associated with increased hip bone loss (25).

Vitamin B12 Deficiency: Video, Anatomy & Definition

Age-related macular degeneration is associated with decreased plasma vitamin B12 levels and increased homocysteine ​​levels. Taking a B12 supplement may prevent the condition (26). However, more thorough studies are needed to understand the mechanism.

Another study also suggested that high levels of homocysteine ​​may increase the risk of age-related macular degeneration (27). Because vitamin B12 helps reduce levels of this amino acid, it could be useful in treating AMD.

Another study in women found that daily supplementation with folic acid, vitamin B12, and vitamin B6 reduced the risk of age-related macular degeneration over a seven-year period (28).

Research shows that supplementing with vitamin B12 along with antidepressants can improve symptoms of depression. B12 deficiency may be associated with depression (29).

Pernicious Anemia: Treatment, Procedure, Cost, Recovery, Side Effects And More

Adequate levels of vitamin B12 can also increase the chance of recovery from depression. However, we need more studies to confirm this finding (30).

The vitamin can also have a beneficial effect on mood. The vitamin is thought to produce brain chemicals responsible for better mood stabilization, although we need more research to understand the mechanism. Anecdotal evidence suggests that it can help treat stress and certain anxiety disorders.

Vitamin B12 in combination with omega-3 fatty acids may also slow memory decline in adults. The nutrient improves cognitive function and also slows the progression of mild cognitive impairment (31).

Another study says the vitamin may prevent brain volume loss in older people. Individuals who consumed sufficient vitamin B12 had a reduced risk of brain shrinkage/atrophy (32).

Vitamin B12 (cyanocobalmin)

XA is a progressive neurodegenerative disease that causes memory and mental impairment due to the shrinkage of brain cells. , although more research is needed to understand the mechanism (33), (34).

Because vitamin B12 also promotes cell formation (a process called methylation), it may help improve symptoms of autism.

XA is a serious developmental disorder that affects an individual’s overall cognitive, emotional and social ability to interact. (35).

Vitamin B12 plays a role in cellular energy production (36). However, there are no studies that claim it can increase energy levels or improve athletic performance as claimed.

Warning Signs That You Have A B12 Deficiency

Research in this aspect is limited. However, one study suggests that adequate levels of vitamin B12 may improve sleep-wake rhythm disorders (38). This study was only done on two patients, so we need more large-scale studies to understand how this vitamin can affect sleep quality.

B12 deficiency is thought to cause insomnia. However, more research is needed to establish the link.

XA disorder characterized by widespread musculoskeletal pain and tenderness accompanied by fatigue, sleep disturbances, and mood problems. and chronic fatigue syndrome. There is a lack of research in this aspect.

One study suggests that vitamin B12 injections may act as pain relievers, helping to treat fibromyalgia (39).

How Vitamin B12 Deficiency Affects The Body

Other studies

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