Most Common Cause Of Low Platelet Count – Camp Lejeune Family Medicine Residency, Naval Medical Center Camp Lejeune, NC (Dr. Temple); Naval Hospital Pensacola, Fla (Dr. Burns)

This algorithm and table will help you quickly evaluate the severity of 2 blood disorders and determine between life-threatening and benign causes.

Most Common Cause Of Low Platelet Count

Do not transfuse platelets in patients with a stable platelet count > 10,000/mcL and not undergoing invasive procedures. C

Postscript • The Blood Project

› Monitor (lifelong) patients with a history of gastric bypass for the development of nutritional neutropenia. C

3. University of Oklahoma Health Sciences Center. Database for drug-induced thrombocytopenia from cohort patient reports: an update. Available at: http://www.ouhsc.edu/platelets/InternetPostingGroupFrames2014.htm. Accessed May 7, 2018.

4. Sniecinski RM, Hursting MJ, Paidas MJ, et al. Etiology and assessment of hypercoagulability with lessons from heparin-induced thrombocytopenia. Anesth Analg. 2011;112:46-58.

6. Connell NT, Sweeney JD. Does the patient have life-threatening or life-threatening thrombocytopenia? Hematol Oncol Clin North Am. 2012;26:369-382.

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9. Sekhon SS, Roy V. Thrombocytopenia in adults: a practical approach to evaluation and management. Med Kidul J. 2006;99:491-498.

12. Yeh JJ, Tsai S, Wu DC, et al. P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection. blood. 2010;115:4247-4253.

13. Stasi R, Sarpatwari A, Segal JB, et al. Effect of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systemic review. blood. 2009;113:1231-1240.

14. Weinzierl EP, Arber DA. Differential diagnosis and bone marrow evaluation of new onset pancytopenia. Am J Clin Pathol. 2013;139:9-29.

Recent Advances In The Mechanisms And Treatment Of Immune Thrombocytopenia

16. Neunert C, Lim W, Crowther M, et al. The American Society of Hematology 2011 evidence-based practice guidelines for immune thrombocytopenia. blood. 2011;117:4190-4207.

17. Kaufman RM, Djulbegovic B, Gernsheimer T, et al. Platelet transfusion: a clinical practice guideline from the AABB. Ann Int Med. 2015;162:205-213.

18. Palmblad J, Dufour C, Papadaki HA. How to diagnose neutropenia in adult and elderly patients. hematology. 2014;99:1130-1133.

19. Hsieh MM, Everhart JE, Byrd-Holt DD, et al. Prevalence of neutropenia in the US population: age, sex, smoking status, and ethnic differences. Ann Intern Med. 2007;146:486-492.

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25. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis caused by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-665.

26. Bhatt V, Saleem A. Review: drug-induced neutropenia – pathophysiology, clinical features, and management. Ann Clin Lab Sci. 2004;34:131-137.

28. Bakken JS, Krueth J, Wilson-Nordskog C, et al. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA. 1996;275:199-205.

29. Hall GW, Schwartz RP. White blood cell count and differential in Rocky Mountain spotted fever. NC Med J. 1979;40:212-214.

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30. Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibodies and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797-808.

31. Petri M, Orbai AM, Alarcón GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Rheumatic Arthritis. 2012; 64:2677-2686.

Thrombocytopenia and neutropenia are common laboratory abnormalities. The presence of either requires you to quickly evaluate for life-threatening causes and identify the appropriate etiology. This article identifies important questions to ask. It also includes algorithms and tables that will facilitate the evaluation of patients with isolated thrombocytopenia or isolated neutropenia and expedite appropriate treatment methods.

Blood abnormalities may be suspected based on the patient’s signs or symptoms, such as ecchymoses, petechiae, purpura, epistaxis, gingival bleeding, or melena, or discovered during a complete blood count (CBC).

Low Platelet Count (thrombocytopenia): Signs, Causes & Treatment

The development of clinical symptoms is closely related to the severity of thrombocytopenia, with a platelet count of <30,000/mcL more likely to cause clinical symptoms with minor trauma and a count of <5,000/mcL that can cause spontaneous bleeding. While most patients have asymptomatic, incidentally discovered thrombocytopenia, and likely benign etiology, those with newly described signs/symptoms, evidence of infection, or thrombosis are more likely to have a serious etiology and require prompt treatment. Although pregnancy may be associated with thrombocytopenia, this review is limited to causes of thrombocytopenia in nonpregnant adults.

When isolated thrombocytopenia is discovered incidentally in an asymptomatic person, the first step is to perform a repeat CBC with a peripheral smear to confirm the presence of thrombocytopenia, rule out laboratory errors, and evaluate for platelet clumping. If thrombocytopenia is confirmed and platelet clumping is present, it may be due to the calcium chelator in the ethylenediaminetetraacetic anticoagulant contained in the laboratory transport tube; This cause of pseudothrombocytopenia occurs in up to 0.29% of the population.

Once true thrombocytopenia is confirmed, the next step is to review the patient’s prescribed medications, as well as over-the-counter medications, for potential causes of drug-induced thrombocytopenia. DITP can be immune or non-immune mediated.

Immune-mediated drug-induced thrombocytopenia usually occurs within 1 to 2 weeks of drug exposure and begins to improve within 1 to 2 days of drug discontinuation.

Low Platelet Count: Why It Happens And How To Treat It

Immune-mediated DITP usually occurs within 1 to 2 weeks of drug exposure and begins to improve within 1 to 2 days of drug discontinuation.

For a list of drugs that may cause thrombocytopenia.) It should be noted that most patients taking the drugs listed in TABLE 1 do not develop thrombocytopenia; still, it is a potential risk associated with using it.

Heparin-induced thrombocytopenia (HIT) is a unique form of immune-mediated DITP because it is caused by an antibody complex, which causes platelet activation, clumping, and thrombotic events.

HIT occurs in 50% within 5 to 14 days after the introduction of heparin; However, in people previously exposed to heparin, it can occur within 24 hours.

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3. University of Oklahoma Health Sciences Center. Database for drug-induced thrombocytopenia from cohort patient reports: an update. Available at: http://www.ouhsc.edu/platelets/InternetPostingGroupFrames2014.htm. Accessed May 7, 2018.

Does Oral Chemotherapy Venetoclax Combined with Rituximab Improve Survival in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia? Low Platelet count is an alarming condition for both doctors as well as patients; in medical terms, it is called Thrombocytopenia. Platelets are your platelets, and penia means a decrease in number. So, this is a condition where your platelet count is low.

Have you noticed that the bleeding from the wound stops after a while? Bleeding stops because of platelets (blood cells). These platelets clump together to form a blood clot.

A normal platelet count range is 150,000 – 450,000 platelets per microliter of blood. If the number of platelets reaches below 150,000 / microliter of blood, a severe condition will develop known as Thrombocytopenia.

Treatment Of Drug Induced Immune Thrombocytopenias

Now, let’s dive into some more details and get a clear picture of how this severe condition occurs. Sometimes the cause is unknown, but mainly, various factors cause this bleeding disorder.

Now, if the production of platelets by the bone marrow decreases or the destruction of platelets occurs at a higher level, Thrombocytopenia develops.

You may ask how come the bone marrow fails to produce platelets? Yes, it happens because of quinine, sulfonamides, anticancer drugs, Heparin, alcohol intake, etc.

Sometimes, platelets get stuck in the spleen (an organ that fights infection). And prevent platelets from circulating in the bloodstream. Therefore, it causes a low number of platelets in the blood.

Why Do Platelets Decrease When You Have Dengue Fever?

One of the main causes of Thrombocytopenia is drug-induced Thrombocytopenia. The most common drug used in patients undergoing surgery is Heparin.

It is observed that during the administration of Heparin, patients tend to develop blood clots. This happens due to the formation of antibodies that initiate the formation of clots.

When you visit the doctor, he will take a medical history to understand the extent and cause of the disease.

You will be asked about your bleeding history, duration, medication history, alcohol use, and recent blood transfusion history.

Pdf) Platelets In Dengue Infection

You will also be asked about your family history of similar conditions and recent exposure to Heparin.

3. With more advanced techniques, anti-platelet IgG antibodies can be detected on the surface of platelets. These antibodies will attack the platelets causing them to decrease in number.

4. Reduced life of platelets, sometimes less than an hour compared to the normal life of 7-10 days.

2. Revalode 25mg (Eltrombopag) – It acts as a platelet growth factor. It will treat chronic immune-mediated thrombocytopenic purpura (ITP) in adults.

Do You Have A Low Platelet Count? Here’s How To Treat It Dr. Axe

If you find a random situation that puts you at risk for Thrombocytopenia, it is important to avoid potential risks to ensure your well-being. A low platelet count can lead to bleeding and injury.

It is very important to consult a doctor if you find signs and symptoms associated with Thrombocytopenia. You should seek immediate medical help in cases of heavy bleeding that cannot be controlled with first aid. You can certainly do a lot to make some changes in your lifestyle by adopting a nutritious diet.

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Idiopathic Thrombocytopenic Purpura (itp)

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