Low Rbc And Wbc But Normal Platelets – Platelets are made in the bone marrow, as are red blood cells and most white blood cells. Platelets are produced from very large bone marrow cells called megakaryocytes. As megakaryocytes develop into giant cells, they undergo a fragmentation process that results in the release of more than 1,000 platelets per megakaryocyte. The predominant hormone controlling megakaryocyte development is thrombopoietin (often abbreviated as TPO).

Platelets are actually not real cells, but merely circulating cell particles. But even though platelets are just fragments of cells, they contain many structures that are crucial to stopping bleeding. They contain proteins on their surface that allow them to stick to cracks in the blood vessel wall and to stick to each other. They contain granules that can secrete other proteins needed to create a firm plug to seal blood vessel cracks. Platelets also contain proteins similar to muscle proteins that allow them to change shape when they become sticky.

Low Rbc And Wbc But Normal Platelets

The images above show normal platelets on the left. They are shaped like a saucer, hence their name. When platelets are stimulated by a break in the blood vessel wall, they change shape as shown in the other three images. They become round and extend the long filaments. They can even look like octopuses, with long tentacles reaching out to contact a broken blood vessel wall or other platelets. With these long filaments, the platelets then form a plug to close the broken blood vessel.

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In addition to being the smallest blood cell, platelets are also the lightest. Therefore, they are pushed from the center of blood flow to the wall of blood vessels. There, they roll along the surface of the vessel wall, which is lined with cells called endothelium. The endothelium is a very special Teflon-like surface that prevents anything from sticking to it. However, when an injury or cut occurs and the endothelial layer is broken, the strong fibers surrounding the blood vessel are exposed to flowing blood. Platelets are the first to respond to injury. The tough fibers that surround the vessel wall act as a sheath and attract the platelets like a magnet, promoting the shape change shown in the images above, and the platelets then stick to these fibers, providing an initial seal to prevent bleeding, leakage of red blood cells and plasma through vessel damage.

A color photograph is a microscopic image of a drop of blood spread on a slide. The magnification is not as high as in the images above, so the platelets look very small. We can see that when the platelets touch the glass, they start to stick together and form a long string. This illustrates the basic function of platelets to stick to any foreign surface and then stick together. The red blood cells in this image are normal, round in shape and thin in the center.

The most common disorder of platelet function is caused by aspirin. Aspirin blocks one of the steps necessary for platelets to stick together. This effect of aspirin is what makes it an effective treatment for patients who have blood clotting disorders or thrombosis. For example, a person who comes to the emergency room with severe chest pain and a suspected heart attack is immediately given aspirin. This prevents some platelets from sticking together, which can impede blood flow to the heart. Aspirin is an effective medicine to prevent these clots, but it does not completely paralyze the platelets. That’s why many people take aspirin daily and have no problems with bleeding. However, aspirin can be potentially dangerous in patients who are already at risk of bleeding, such as boys with hemophilia or patients who have too few platelets and are dependent on each platelet to function fully.

Rare conditions cause the bone marrow to produce too many platelets, sometimes as many as a million or two million per microliter. Some of these patients have an increased risk of blood clots, but many patients with these disorders have no problems.

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Diseases with low platelet counts are called thrombocytopenia, a term derived from the old name for platelets, “platelets.” This name describes platelets as cells (“cytes” being the word for cell) that contribute to thrombosis, or blood clotting. The last part of the word, “-penia”, refers to having too few cells.

Thrombocytopenia is the main topic of this website. Thrombocytopenia can be caused by the failure of the bone marrow to produce a normal number of platelets. Bone marrow failure has several causes. They are not discussed on this site.

Thrombocytopenia can also be caused by increased destruction of platelets as they are produced and released into the bloodstream. These disorders are the focus of this website. They are described briefly here, and in more detail in their specific sections on this website.

The information on this site is for educational purposes only. The designers and operators of this site take no responsibility for what you may do with this information. Consult your healthcare provider for advice about your unique medical condition. By continuing to use this website, you acknowledge that you have read and understood this disclaimer. Before starting treatment, doctors perform various tests to diagnose your disease. The most common of these tests is a complete blood count (CBC), which is a blood test. It provides information about your blood and general health to your primary care physician (PCP). CBCs help PCPs diagnose, monitor, and screen for a wide variety of diseases, conditions, disorders, and infections. Your provider draws a blood sample and your lab results are usually ready within a few days.

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A complete blood count (CBC) is a type of blood test. It helps healthcare providers differentiate the range of problems and conditions. It also checks your blood for signs of side effects of the medicine. Providers use this test to assess disease and change medications.

A complete blood count measures and counts your blood cells. Your primary care physician requests a sample of your blood and sends it to a laboratory for further testing. The laboratory performs a series of tests to evaluate your blood cells. These tests help your provider check your health.

A complete blood count (CBC) is a blood test used to assess your general health and diagnose many problems, including anemia, leukemia, and any infection. A complete blood count test evaluates several components and elements of your blood, including:

An abnormal increase or decrease in a cell, including a finding in a complete blood count, may indicate that you have an underlying medical condition that requires further evaluation.

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Your primary care physician may arrange for a CBC as part of a routine exam or on the other hand if you have unexplained symptoms such as bleeding or bruising. A CBC can help your PCP keep track. A complete blood count is a typical blood test that is done for a variety of reasons:

During a CBC, a lab technician will draw blood from a vein, often from your elbow or the back of your hand. The test will take a few moments. Technician:

A blood test can be a bit awkward. At the point where the needle enters the skin, you may feel a prick or pinch. Some individuals also feel weak or confused when they see blood. Minor bruising may occur later, but it will disappear within a few days. Most CBC results are available within a few hours to a day after testing.

For babies, the health care provider (nurse) will usually disinfect the site of the bump on the foot and use a small needle called a lancet to prick the area. The healthcare provider will then gently apply pressure to the heel at this point and collect a limited amount of blood into a vial for testing.

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Results are usually ready within a few days. However, sometimes it only takes 24 hours for the results to be ready. Your provider will contact you to understand the results and discuss the next steps. Assuming your blood cell count is outside the normal range, your provider can arrange for further testing.

A CBC blood test can help your doctor diagnose many primary and urgent health problems, illnesses, and diseases, including:

A CBC gives your provider a picture of your overall health. Using a limited amount of blood, a CBC can help differentiate many conditions, problems, and diseases. It allows your provider to monitor your health, screen for disease, and plan and modify treatment. A CBC is a proprietary, routine test. There are no risks involved and your provider only draws a modest amount of blood. It is rare for some individuals to feel a bit weak or drunk after CBC.

Health care providers use whole blood composition to control infection and help you stay healthy. With a single blood sample, a CBC can help detect many problems, conditions, and diseases. CBC can identify conditions early, in some cases before you

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