Dog High White Blood Cell Count Cause – We often think of leukemia as a disease that affects humans. However, like many other diseases, leukemia can also affect pets, including cats and dogs. Here is a starter guide to understanding more about canine leukemia.

Canine leukemia is a cancer of the lymphatic system that occurs when the immune system produces too many cancerous white blood cells. These white blood cells, called lymphocytes, naturally swell in number due to certain stimuli that prompt the immune system to activate. Leukemia is the dangerous overproduction of these cells. These lymphocytes develop in the bone marrow or lymph nodes. With canine leukemia, the body will produce an excess of cancerous lymphocytes at the expense of other necessary blood cells.

Dog High White Blood Cell Count Cause

Dog High White Blood Cell Count Cause

There are two different types of canine leukemia: chronic and acute. There are several distinctions between the two general types of leukemia, including signs, age, and severity. Leukemia is usually diagnosed with a blood test that would reveal an extremely high number of lymphocytes.

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Acute lymphocytic leukemia (ALL) often occurs in younger dogs, with the average age of diagnosis being 6.2 years. Just over a quarter of affected dogs are under the age of four, according to Veterinary Partner. ALL is characterized by a high population of lymphoblasts, which are immature lymphocytes. On examination, these dogs often have a deficiency of a variety of blood cells due to the predominance of cancerous white blood cell production.

Canines can be deficient in platelets, red blood cells (red blood cell deficiency is also called anemia), and a certain type of white blood cell called neutrophils. Dogs with canine leukemia may also have an enlarged spleen and liver. They may also have enlarged lymph nodes.

Symptoms of acute leukemia include weight loss, lethargy, nausea, diarrhea and lack of appetite. ALL is a more aggressive form of leukemia and therefore requires intense chemotherapy in addition to possible blood transfusions due to anemia (read more about anemia in dogs.) Unfortunately, due to the aggressive nature of ALL, few pets make a full recovery even with treatment . Untreated dogs could die within weeks.

Chronic lymphocytic leukemia (CLL) is much less severe than ALL and occurs mostly in older dogs between 10 and 12 years of age. There are three different types of CLL and they affect dogs differently, so it’s important to get a blood test to reveal which type of CLL a dog has. Dogs with the T-cell version of CLL have the best predicted survival time, although CLL is generally less malignant than ALL.

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Many dogs show no symptoms of CLL, so the cancer is only discovered during a routine blood test at the vet. If the pet is asymptomatic and the lymphocyte count is below a certain level, treatment may not even be recommended. Dogs with CLL can live up to several years after initial diagnosis, with a fairly good quality of life .

Vets will look for a few key indicators to determine if your pet has ALL or CLL. The age of the dog and its symptoms are two main factors used to distinguish between the two conditions. As previously mentioned, ALL has a more significant and visible toll and occurs more often in younger dogs. Another factor used to differentiate the two is the maturity of the lymphocytes when inspecting the blood cells. Cancer cells in dogs with chronic leukemia are more developed and mature than cells in dogs with acute leukemia.

It is often difficult to attribute leukemia to a specific cause. Certain breeds, such as golden retrievers and German shepherds, are predisposed to CLL. Exposure to radiation and benzene has been linked to leukemia in humans, so it is possible that exposure to these toxins can cause leukemia in dogs as well.

Dog High White Blood Cell Count Cause

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Hypereosinophilic syndrome is a disorder that results from an overproduction of white blood cells in the bone marrow in dogs. It can occur spontaneously and the exact cause is not known. It is characterized by an increased number of eosinophils in the dog’s blood and can occur due to a response to certain drugs, parasites or allergens. This blood disorder is known to lead to hepatitis and other abnormal organ functions. Abnormal organ function is the result of eosinophil infiltration into tissues. Organs and organ systems commonly affected are the spleen, lungs, lymph nodes, gastrointestinal tract, and bone marrow.

Canine bone marrow overproduction, or hypereosinophilic syndrome, is the abnormally high amount of eosinophils, or white blood cells, in a dog’s blood. This leads to organ damage with an overpopulation of eosinophils within the organ tissue.

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If your dog shows any symptoms that may indicate hmi is feeling unwell, or if you see behavioral changes, it is very important to make an appointment with the vet. Symptoms of an overproduction of white blood cells in the bone marrow in dogs include:

Although this rare disease can occur in any breed of dog, whether purebred or mixed, this disorder is known to be more prevalent in certain dog breeds. Breeds predisposed to overproduction of white blood cells in the bone marrow are:

The exact cause of hypereosinophilic syndrome is unknown. Research is ongoing in an effort to learn more about this rare condition, which affects both humans and canines. What is known is that white blood cells (called eosinophils), present in circulating blood, are much higher in number than normal. These cells may also infiltrate tissues, causing organ involvement in the form of tissue thickening (such as the spleen, gastrointestinal tract, and lungs).

Dog High White Blood Cell Count Cause

Your vet will listen to your concerns and ask questions about the onset and severity of symptoms. He will also take a look at the dog’s health history. The first course of action will be to do a complete blood count, check for hypereosinophilia. If there is a noticeable increase in white blood cells, the vet will perform a bone marrow biopsy to reveal the condition even more. The doctor may perform a bronchoscope test, called a bronchoalveolar lavage, to analyze a fluid collected after it is taken into the lungs, which will then be tested for increased amounts of eosinophils. Biopsies of many different organs will also be performed.

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Other tests, including cytogenetic analysis, serum analysis, and biochemistry may also be performed, primarily to differentiate this disease from leukemia. The veterinarian should also rule out fungal infections, eosinophilic cellulitis, mast cell tumors, eosinophilic bronchopneumopathy, parasitic infections, and eosinophilic enteritis.

Treatment will require long-term commitment to treatment to reduce the abnormal white blood cell count and treat any organ damage. Methods include:

Prednisone can be given to reduce the inflammation and give the dog a much better long term prognosis.

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Depending on the treatment given, the doctor will have instructions for you to follow regarding aftercare and treatment. Regular veterinary visits will be required to monitor the dog’s production of white blood cells and to monitor the damaged organs to see if they are improving. It will be important to monitor side effects from the treatment given, and the prognosis of this disorder varies greatly depending on the amount of eosinophil infiltration into the tissue of the affected organ.

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Dog High White Blood Cell Count Cause

Chronic leukemia is a cancer of the blood and occurs when an abundance of white blood cells are produced rapidly. It usually affects middle-aged to old dogs and develops slowly, with no visible symptoms specific to the condition. When chronic leukemia is diagnosed, you can maintain your dog’s condition through a combination of consistent monitoring and chemotherapy, which can prolong

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