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What Is The Difference Between Metformin And Metformin Er

Metformin is a commonly prescribed drug used to treat type 2 diabetes mellitus. It is an antidiabetic agent that belongs to a class of drugs known as biguanides. It works by reducing the production of glucose (blood sugar) in the liver, reducing the absorption of glucose in the intestines, and enhancing insulin sensitivity. Metformin improves insulin sensitivity by increasing the absorption of glucose in body tissues.

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Type 2 diabetes mellitus is diagnosed when the body becomes resistant to the effects of insulin. Insulin is an essential hormone produced by the pancreas and used to transport glucose into the body’s cells for energy. When the body cannot use insulin properly, blood sugar levels rise which can cause damage to blood vessels and nerves. Without proper treatment, diabetes can lead to complications and damage to organs such as the heart and kidneys.

Metformin is available in immediate-release (IR) and extended-release (ER) forms. While both forms of metformin contain the same active ingredient, they are taken in different ways. They also have some differences in side effects.

Metformin or metformin hydrochloride is the generic name for Glucophage. Immediate-release metformin is usually dosed as a 500 mg tablet taken twice daily with food. There is also an 850 mg tablet that can be taken once a day. The maximum dose of metformin is 2550 mg per day in divided doses. Metformin can treat type 2 diabetes in both adults and children.

Metformin ER is also known by the brand name Glucophage XR. It is the extended release version of metformin and only needs to be taken once a day with food. The maximum total daily dose of metformin ER is 2000 mg. Unlike immediate-release metformin, metformin ER is only indicated for adults with type 2 diabetes. It also has fewer side effects and lasts longer than regular metformin.

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Both metformin and metformin ER are FDA-approved to manage type 2 diabetes mellitus. According to the American Diabetes Association (ADA), metformin is the first-line treatment for diabetes -type 2. In patients with A1c less than 9% at the time of diagnosis, metformin should be started as monotherapy according to the Standards of Medical Care in Diabetes. Metformin can help improve glycemic control and ultimately prevent complications that can arise from diabetes.

Not only can metformin be used to treat type 2 diabetes, but it can also be used for off-label purposes. Those with prediabetes and high fasting plasma glucose (FPG) may be recommended metformin to prevent the onset of diabetes. Metformin is recommended when blood sugar levels are not managed by diet and exercise alone.

Metformin can also be used as an off-label option for the treatment of gestational diabetes mellitus. This type of diabetes occurs in pregnant women who are predisposed to diabetes. However, insulin is usually tried first.

Metformin has also been studied to treat polycystic ovary syndrome (POCS). This syndrome is characterized by an imbalance of sex hormones that can result in ovarian cysts, changes in the menstrual cycle, pregnancy issues, acne, and insulin resistance. Metformin can be prescribed to help reduce insulin resistance, lower testosterone levels, and improve menstrual cycles as well as fertility.

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The use of antipsychotic drugs, such as olanzapine, risperidone, and clozapine, can lead to weight gain. According to some studies, Metformin has been shown to be effective in treating weight gain caused by antipsychotics. One review found that metformin helped reduce body mass index (BMI), body weight, and insulin resistance compared with placebo in those with weight gain caused by from antipsychotics.

Based on studies comparing metformin and metformin ER for type 2 diabetes mellitus, metformin ER was found to be comparable to metformin in efficacy. In fact, metformin ER may be superior to regular metformin based on its lower side effect profile and ease of use. Those with type 2 diabetes mellitus may be more inclined to take a metformin tablet once a day instead of a tablet twice a day.

In one randomized, clinical study, metformin ER was found to be more effective than metformin IR when treating patients with type 2 diabetes. Those who took metformin ER experienced better glycemic control and lipid metabolism compared to metformin IR.

Another randomized, double-blind trial found that once-daily metformin ER had similar efficacy and safety to regular metformin. In addition, the study noted an advantage of once-daily dosing with metformin ER. Both metformin and metformin ER improved HbA1c levels over 24 weeks in subjects who had never tried any other treatment for their diabetes.

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Extended-release metformin may be preferred over immediate-release metformin. It has been shown to have better tolerability although it may be more expensive than immediate-release tablets. It is important to consult medical advice from a healthcare professional when choosing a treatment option for type 2 diabetes mellitus.

Metformin is the generic version of Glucophage. Generic metformin is covered by Medicare part D and most insurance plans. Brand name Glucophage can be quite expensive and cost an average retail price of over $150. This cost can be reduced by bringing a discount card to the pharmacy. The metformin card can bring the cost down to $4 for a 30-day supply of generic immediate-release metformin.

Almost all Medicare and insurance plans will cover generic metformin ER. Brand name Glucophage XR can cost around $80 depending on the pharmacy you go to. With a coupon card, generic metformin ER can be purchased for as little as $4 for a 30-day supply of once-daily metformin ER tablets. Even with insurance, they may be able to offer a lower price. Check with your pharmacy to see if you can take advantage of a better discount with .

Metformin causes side effects that affect the gastrointestinal (GI) system. These side effects include diarrhea, nausea, vomiting, gas (flatulence), indigestion, and abdominal discomfort or upset stomach. Metformin IR also commonly causes fatigue or lack of energy (asthenia) as well as headaches.

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Metformin ER has fewer side effects compared to metformin. The most common side effects associated with metformin ER are diarrhea, nausea, and vomiting. Metformin ER can also cause constipation in some people. Although metformin ER can cause other GI side effects such as indigestion and flatulence, these side effects do not occur as often compared to regular metformin.

Other side effects that can occur with metformin and metformin ER include dizziness, lightheadedness, and taste disturbances. Other more serious side effects of metformin and metformin ER include liver damage and hypoglycemia (low blood sugar).

Metformin and metformin ER can interact with several different drugs. Drug interactions often result in changes in blood glucose, increased risk of lactic acidosis, or accumulation of metformin in the blood that can increase the risk of adverse effects.

Taking metformin with medicines called carbonic anhydrase inhibitors can increase the risk of lactic acidosis, a potentially life-threatening condition from too much lactate in the body. These drugs include topiramate and acetazolamide among others.

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Medicines such as dolutegravir, cimetidine, and ranolazine can decrease the clearance of metformin. This can result in high levels of metformin in the blood and increase the risk of adverse events.

Other drugs such as diuretics, corticosteroids, phenothiazines, oestrogens, oral contraceptives and calcium channel blockers may interfere with glucose control. Taking any of these medicines with metformin can result in hyperglycaemia (dangerously high blood sugar). The use of insulin or sulphonylurea medicine or glinide with metformin may cause an increased risk of hypoglycemia.

This may not be a complete list of all possible drug interactions. Consult a doctor with all medications you may be taking.

Metformin may cause lactic acidosis in rare cases. Lactic acidosis occurs when there is too much lactate in the blood. This condition can result in low blood pressure, hypothermia, and even death. Other symptoms of lactic acidosis include unusual weakness, diarrhea, stomach pain, and cramps. Seek immediate medical attention if you exhibit these symptoms.

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Metformin can reduce the levels of vitamin B12 in the body. Over time this can lead to vitamin B12 deficiency. Vitamin B12 levels should be monitored every 2 to 3 years when taking metformin long-term.

Although rare, metformin can cause hypoglycaemia if taken with insulin or an insulin secretagogue such as glipizide or repaglinide. In rare cases, metformin can cause hypoglycemia when taken with alcohol or an inadequate diet.

Metformin is a prescription medicine approved to treat type 2 diabetes mellitus in adults and children 10 years of age and older. Immediate-release metformin is usually taken twice a day with meals. It is considered a first-line treatment for type 2 diabetes when combined with a proper diet and exercise routine.

Metformin ER is the extended release form of metformin. It is also known by the brand names Glucophage XR, Glumetza, or Fortamet. Metformin ER lasts longer than regular metformin and has fewer side effects. It is prescribed once a day with an evening meal.

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No. Metformin and metformin ER are not the same. Metformin is the immediate release version while metformin ER is the extended release version. Metformin is approved to treat type 2 diabetes in adults and children 10 years of age and older

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