What Are The Negative Effects Of Melatonin – Melatonin is a hormone that plays a significant role in regulating sleep and circadian rhythms. Nicknamed the sleep hormone, melatonin forms in the brain’s pineal gland in response to declining light levels to prepare the body for sleep.

In recent years, melatonin supplements marketed to treat a variety of sleep disorders have become common. From 2007 to 2012, melatonin use in the United States doubled. Trustworthy Source National Library of Medicine, Biotech Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source and is now considered one of the most popular supplements in the nation. Its popularity stems in part from its image as a natural alternative to traditional sleep medications, which are known for their side effects. However, this does not mean that melatonin supplements are harmless.

What Are The Negative Effects Of Melatonin

It is important to be aware of the safety risks of taking too much melatonin. Let’s take a closer look at melatonin dosage, potential symptoms of a melatonin overdose, and when to contact a doctor.

Melatonin For Sleep: Side Effects & Dosage

Melatonin is available for purchase in any quantity, without a prescription in the United States. However, there is currently no formal consensus on the optimal dosing regimen for this supplement. Studies often use doses ranging from 0.1 to 10 milligrams Trustworthy Source National Center for Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source, but 1 to 5 milligrams is often considered an adequate amount to start with.

There are many challenges in determining the appropriate amount of melatonin to take for each person. Individual responses to this supplement may vary considerably due to factors that are not fully understood but may include age, gender, specific sleep problems, other health conditions, and timing of administration.

Additionally, not all melatonin supplements are created equal. Differences in preparation can significantly alter Trusted Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View the impact of melatonin on the source. Depending on the formulation, taking 1 to 10 milligrams of melatonin can increase the body’s blood melatonin levels by 3 to 60 times the normal amount.

Melatonin users should also be wary of dosages listed on supplement labels, which have been found to be alarmingly inaccurate. A Random Sampling Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View Source of 31 brands of melatonin supplements determined that most did not contain the labeled dose, with the actual amount ranging from less than 80% to nearly 500%. Additionally, over a quarter of the supplements contained serotonin.

What Happens To Your Body When You Take Melatonin Every Night

Despite a lack of data and variability in dosing regimens, with typical use, melatonin is widely considered safe. Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source and is generally well tolerated in healthy adults. The Risk of Side Effects Trustworthy Source The National Center for Complementary and Integrative Health (NICCH) NCCIH funds and conducts research to help answer important scientific and public health questions about complementary health approaches. View source is low, but may include mild headache, dizziness, nausea, and drowsiness.

The safety and effectiveness of supplements are not closely monitored by the U.S. Food and Drug Administration (FDA). Buyers should take additional measures to ensure they purchase reliable products.

So far there is no clinical evidence that short-term melatonin use can cause long-term problems in healthy adults. However, it is important to discuss melatonin supplementation with your doctor, as he or she can help you determine the correct dosage. It is generally recommended to start with the lowest possible dose. This can help prevent unwanted side effects.

It is also important to note that high-quality studies involving higher doses of melatonin are lacking. The current body of evidence consists mainly of small studies and case reports.

Will Melatonin Help My Child Sleep Through The Night?

In one study, 12 adult males were given intravenous melatonin Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source in doses of 10 milligrams, 100 milligrams, or a placebo. No differences in sedation were reported between groups and no harmful reactions occurred. A second study gave five patients 1,000 milligrams of oral melatonin. Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source for about four weeks. Although changes in pituitary hormones have been observed, no toxic effects have been reported.

Unwanted or concerning side effects can occur with any supplement, even if it is considered relatively safe. Concerning symptoms have been reported with higher doses of melatonin.

Because melatonin can affect the cardiovascular, dermatologic, and central nervous systems, those with other conditions may be vulnerable to additional risks. Evidence suggests that melatonin supplementation may induce depression Trustworthy Source Merck Manual First published in 1899 as a small reference book for doctors and pharmacists, the Manual has grown in size and scope to become one of the world’s most comprehensive medical resources. used by professionals and consumers. View source, particularly in people predisposed to or currently experiencing it. Research on this topic, however, is mixed, as some studies have demonstrated melatonin’s potential in treating depression. Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. See the source.

People taking anticoagulants and benzodiazepines should be careful, as the possibility of interaction exists. Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. See the source. Those with epilepsy should also exercise caution, as melatonin has been associated with increased seizures. People who are currently taking other medications or supplements should discuss potential interactions directly with their doctor before taking melatonin.

The Surprising Side Effects Of Melatonin: What You Need To Watch Out For

Research suggests that older people, who have lower natural levels of melatonin Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information . View source, they may be more sensitive to the effects of melatonin supplements. Therefore, older people are encouraged to consult their doctor before taking melatonin and start with the lowest possible dose.

Compared to most other sleeping pills, melatonin cleanses the body quickly and its effects are short-lived. If you experience unwanted symptoms after taking melatonin, you can most likely simply wait for your body to process the drug. However, if in doubt, it is always a good idea to seek professional advice. Don’t hesitate to contact your doctor or local poison control center for guidance on managing concerning symptoms or to determine if you need medical attention.

There is minimal research on the use of melatonin beyond a few months. Therefore, there is a lot we don’t know about its long-term effects. There is also no agreement on what constitutes long-term melatonin use.

Most of the concerns about taking melatonin for extended periods involve its potential effect on reproductive hormones. Although the exact mechanism of action is still unclear, some reports indicate that melatonin may inhibit reproductive hormones Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. See the source.

Melatonin Mistakes Sleep Doctors Want You To Avoid

More research needed on the safety of melatonin Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source for kids.

Nearly 25% of children have trouble sleeping Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source and parents are increasingly turning to melatonin for help. Between 2007 and 2012, pediatric melatonin use increased seven-fold. Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source and is now the second most common natural supplement in this age group.

Despite its prevalence, there are reasons why parents should be cautious about using melatonin. It appears that children may be particularly vulnerable to the possible effects of this supplement on reproductive hormones. Melatonin has been associated with delays in puberty Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. View source , irregular menstruation and overproduction of the hormone prolactin. It is important to note, however, that research on this topic is conflicting Trustworthy Source National Library of Medicine, Biotechnology Information The National Center for Biotechnology Information advances science and health by providing access to biomedical information

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