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® is a pegfilgrastim biosimilar treatment that stimulates the growth of neutrophils, a type of white blood cell in the body’s fight against infection after chemotherapy. Granulocyte uses a man-made form of a protein called colony-stimulating factor (G-CSF) – a substance produced naturally by the body.

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Febrile neutropenia is the development of fever in a patient with an elevated white blood cell count. Call your health care team right away if you have a fever of 100.4°F (≥38.0°C) or higher.

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It is important to discuss any transportation concerns you may have with your healthcare team Missing a dose of A can affect your chemotherapy treatment schedule

These are not all possible side effects Call your doctor for medical advice about these and other side effects You can report side effects to the FDA at 1‑800 – FDA – 1088

If you’ve been prescribed one, sign up for reminders and supportive resources to guide and support you through treatment.

, a biosimilar treatment, is a humanized form of granulocyte colony-stimulating factor (G-CSF). G-CSF is a substance produced by the body It stimulates the growth of neutrophils, a type of white blood cell important in the body’s fight against infection.

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Biosimilars are FDA-approved biologic medications that are as safe and effective as the original biologic (known as the reference product). Biosimilars have no clinically meaningful differences from the reference product. This means that there is no compromise on the safety and efficacy of the biosimilar compared to the reference product. Biosimilars introduce competition in the market and can lower the cost of cancer treatments

Source: Biosimilars and Interchangeable Products US Food and Drug Administration Updated April 27, 2023 Accessed April 27, 2023 https://www.fda.gov/drugs/biosimilars/biosimilar-and-interchangeable-products#nodiff

Chemotherapy works by targeting cancer cells It also affects and reduces the number of healthy infection-fighting white blood cells.

, tell your health care provider about all your medical conditions, if you have a sickle cell disorder, kidney problems, are pregnant or plan to become pregnant (it is not known if

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Tell your health care provider about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Pain in bones, arms and legs These are not all possible side effects

. Talk to your doctor about bone pain and any other side effects Be sure to review the patient information for more side effect information

An injection (subcutaneous injection) is given under your skin by a healthcare provider one day after chemotherapy treatment.

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. It is important not to miss this appointment, so discuss any transportation questions with your healthcare team prior to treatment.

References: 1.® (pegfilgrastim-cbqv) Patient Information Redwood City, CA: Coherus Biosciences, Inc.; 2023. 2. TaiE, GuyGP, DunbarA, Ital Hospitalizations for cancer-related neutropenia or fever, United States, 2012. Junkl Practice. 2017; 13(6):e552-e561 3. Relevance of febrile neutropenia in oncology AmJ Manage Care. Supplement published April 27, 2023. Accessed April 27, 2023.

A man-made form of granulocyte colony-stimulating factor (G-CSF). G-CSF is a substance produced by the body It stimulates the growth of neutrophils, a type of white blood cell important in the body’s fight against infection.

The most common side effects of ® are pain in the bones, arms, and legs These are not all possible side effects

Low Blood Counts

Call your healthcare provider for medical advice about side effects To report SUSPECTED ADVERSE REACTIONS, contact Coherus Biosciences at 1-800-4-(1-800-483-3692) or Low White Blood Cells at 1‑800 – FDA – 1088 or www.fda.gov/medwatch Do it Anemia is a condition where the number of white blood cells in your body becomes too low White blood cells (also called leukocytes) are part of the immune system, and they are cells that protect against infection by bacteria, viruses, fungi, and parasites. A low white blood cell count is also called leukopenia

White blood cells are very important for health Life is impossible without them Disease-causing organisms are literally everywhere, but most people don’t get sick because they have plenty of white blood cells to protect them. A low white blood cell count often means there is a problem in the body, so it is not considered normal

There are several types of white blood cells Each has its own special purpose and different life span There are monocytes (morph into other white blood cells), lymphocytes (release antibodies, regulate the immune system and kill infected human cells), basophils (initiate inflammatory responses), eosinophils (kill parasites and trigger allergic reactions) and neutrophils ( The main killer). bacteria and fungi).

Our bodies constantly produce millions of different white blood cells to replace old or dead ones That’s why their numbers remain relatively constant most of the time The immune system is capable of regulating the activity of white blood cells, increasing or decreasing the number of a particular type as needed under the circumstances. In moments where we put ourselves at risk, such as eating dirty or spoiled food, breathing dust rich with microorganisms, being in crowded places, or being in places like airplanes, gyms, or hospitals, we often don’t get sick because we have a blood clot. A good supply of blood cells that kill pathogens before infection

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If we get sick, the immune system will launch a series of actions to stop or kill the invading disease as well as destroy infected or dying cells in the body. The infection often causes a large increase in the white blood cell count Doctors can easily tell if you have an infection if they see that your white blood cell count is higher than normal. Increased white blood cells make the body more likely to fight infection

However, there are cases where the white blood cell count decreases In most cases, it requires a thorough investigation because it is often associated with health problems, some of which are serious. A low white blood cell count is not a diagnosis or a health condition This is just a finding after a routine blood test

The correct term for a blood test or test is a complete blood count or CBC Doctors often order a CBC because it analyzes the number of cell components, including white blood cells. The normal range for white blood cell counts can vary The Mayo Clinic says the normal range is 3.5 billion to 10.5 billion cells per liter of blood. Meanwhile, Medline Plus says 4,500 to 11,000 white blood cells per microliter (mcL) is normal.

A CBC is the only way to determine the number of white blood cells in the body Your doctor may order several CBC tests to monitor your blood cell count

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The main purpose of white blood cells is to protect the body from infection by microorganisms. If their numbers are too low, you may be prone to infection Most people don’t really experience any symptoms unless their white blood cell count is low

If you have a low white blood cell count for a while, you may have an increased frequency of illness or infection than usual.

Not all organisms, except HIV, are able to attack white blood cells head-to-head. Meanwhile, the main purpose of white blood cells is to kill the organism The body naturally produces more white blood cells when there is an infection or inflammation Explains why infection causes an increase in white blood cells

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As we mentioned earlier, our body is constantly making white blood cells White blood cells are produced in bone marrow, just like other components of blood A low blood cell count means something is wrong with the production of white blood cells

In most cases, a low white blood cell count is the result of an illness Some treatments can also have side effects Malnutrition and malnutrition can also reduce the white blood cell count

Low white blood cell count is often associated with diseases Among the most common causes is a serious infection, which can cause white blood cells to use up faster than they can be produced Serious infections can occur if the disease is not treated or does not respond to treatment. It usually occurs in babies, very young children or the elderly

A low white blood cell count is often a feature of immunodeficiency or a compromised immune system. As you learned in school, white blood cells are the workhorses of the immune system A low number of specific white blood cells in CBC reveals the cause of the immune system Some of the more common conditions that cause immunodeficiency include systemic lupus erythematosus (lupus), tuberculosis, dengue fever virus infection, rickettsia, psoriatic arthritis, Sjögren’s syndrome, Lyme disease, and Hodgkin’s lymphoma.

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HIV infection is also a common cause of low white blood cell count. Human immunodeficiency virus mainly targets the CD T4 helper cells, which actually trigger it.

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