Low White Blood Cell Count And Lymphocytes – DEAR MAYO CLINIC: Recently, my 16-year-old grandson was diagnosed with a low white blood cell count and two episodes of migraine headaches, vomiting, and temporary blindness. What could be the cause of low leukocytes at his age? I am worried it is something serious and am wondering what other tests should be done.

ANSWER: Many diseases and conditions can cause a low white blood cell count. Without more information, it is difficult to say what caused your grandson’s condition. This low number is unlikely to be related to his migraines and other symptoms. It is wise to have another blood test to see if the problem has recurred. His doctor can decide if further evaluation is necessary.

Low White Blood Cell Count And Lymphocytes

Blood has a number of components. In addition to white blood cells that fight infection, red blood cells carry oxygen and platelets help blood clot. Bone marrow, the spongy tissue inside bones, makes blood cells.

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There are several types of white blood cells. Neutrophils fight fungal and bacterial infections. Lymphocytes protect the body from viral infections. Monocytes help get rid of dead or damaged tissue and regulate the body’s immune response. Eosinophils are white blood cells that fight disease. Basophils play a role in wound healing, infection, and allergic reactions.

One of the most common causes of low white blood cells is a viral infection. These infections can sometimes temporarily disrupt the production of blood cells in the bone marrow, causing a low blood cell count. As the body recovers from the infection, the counts usually rise again. For most people, this temporary drop in blood cells has no long-term effects.

Some medications can cause low white blood cells because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics can sometimes cause an abnormal decrease in neutrophils, a condition known as neutropenia. With this in mind, it may be helpful for your grandchild’s doctor to review any medications he is taking to see if they may be causing changes in his blood cell count.

A variety of other conditions and disorders can also cause neutropenia. You can watch this Mayo Clinic video to review this condition and learn more about how to diagnose and treat it.

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The list of other possible causes of low white blood cell counts in a person is long. Autoimmune disorders, congenital disorders that affect bone marrow function, spleen disorders, certain infectious diseases, cancers and parasitic infections, among others, can all cause low white blood cell counts.

A good next step for your grandchild is to have a complete blood count. This test measures components in the blood. This test can help you understand what may be causing your grandchild to have low levels of a certain type of white blood cell, as well as other blood tests.

The other symptoms you mention—headache, blurred vision, and vomiting—should also be addressed with a physical exam, a review of your grandson’s family and medical history, and additional tests recommended by his doctor. Although these symptoms are not related to her low white blood cell count, it is important to investigate and determine their underlying cause. – Carola Arndt, M.D., Pediatric Hematology/Oncology, Mayo Clinic, Rochester, Minn.

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As Daylight Saving Time ends and clocks go back an hour, much of the US and the world will soon be “falling back.” …Leukopia (from the Greek λευκός (leukos) “white” and πενία (pia) “deficiency”) is a decrease in the number of white blood cells (WBC). Found in the blood, they are white blood cells and are the body’s main defense against infection. Thus, the condition of leukopenia increases the risk of infection.

Neutropia, a type of leukopenia, refers to a decrease in the number of circulating neutrophil granulocytes, the most common white blood cells. The terms leukopenia and neutropenia are sometimes used interchangeably because the neutrophil count is the most important indicator of infection risk. Agranulocytosis is an acute form of neutropenia.

A low white blood cell count can be caused by an acute viral infection, such as a cold or flu. It is associated with chemotherapy, radiation therapy, myelofibrosis, aplastic anemia (insufficient production of white blood cells, red blood cells, and platelets), stem cell transplants, bone marrow transplants, HIV, AIDS, and steroid use.

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Other causes of low white blood cell counts include systemic lupus erythematosus, Hodgkin’s lymphoma, certain types of cancer, typhoid fever, malaria, tuberculosis, dengue, rickettsial infections, enlarged spleen, folate deficiency, psittacosis, sepsis, and Sjögr’s syndrome. It is also caused by a deficiency of certain minerals such as copper and zinc.

Pseudoleukopenia may occur early in the infection. Leukocytes (primarily neutrophils that respond to injury) begin to migrate to the site of infection, where they are scanned. Their migration causes the bone marrow to produce more white blood cells to fight the infection and restore white blood cells in the circulation, but when a blood sample is taken at the onset of infection, it has a low white blood cell count, so it is called “pseudoleukopenia.” “.

Drugs that can cause leukopenia include clozapine, an antipsychotic drug that has a rare side effect of causing complete abscessation of all granulocytes (neutrophils, basophils, eosinophils). Bupropion HCl (Wellbutrin) is an antidepressant and can cause leukopenia with long-term use in the treatment of smoking addiction. Minocycline, a commonly prescribed antibiotic, is another drug that can cause leukemia. There are also reports of divalproex sodium or valproic acid (Depakote) being used to treat epilepsy (seizures), mania (with bipolar disorder), and migraines.

The FDA monograph for metronidazole states that the drug may cause leukopenia, and the physician’s information recommends a complete blood count, including a differential cell count, especially before and after high-dose therapy.

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Leukemia is a known complication of immunosuppressive drugs such as sirolimus, mycofolate mofetil, tacrolimus, cyclosporine, leflunomide, and TNF inhibitors.

Chemotherapy targets fast-growing cells, such as tumors, but can also affect white blood cells, as they are characteristic of the bone marrow.

A common side effect of cancer treatment is neutropenia, a decrease in neutrophils (a specific type of white blood cell).

A 2.5 percentile (the positive limits of the intervals in the figure, indicating the 95% predictive intervals) is a common cutoff for the detection of leukocytosis. Stem cells in the bone marrow are responsible for producing white blood cells. Bone marrow stores approximately 80-90% of white blood cells.

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When an infection or inflammatory condition occurs, the body produces white blood cells to help fight the infection.

Health professionals have identified three main categories of white blood cells: granulocytes, lymphocytes, and monocytes. The following sections discuss this in more detail.

Granulocytes are white blood cells with small granules containing proteins. There are three types of granulocyte cells:

Monocytes are white blood cells that make up 2-8% of the total number of white blood cells in the body. These occur when the body fights chronic infections.

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According to an article in American Family Physician, the normal range of white blood cells (per cubic millimeter) for age is:

If a person’s body should have white blood cells, then doctors call it leukocytosis.

If the number of leukocytes in the human body is low, then doctors call it leukopenia.

Doctors may regularly monitor white blood cells to determine whether the body is responding to an infection.

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During a physical exam, your doctor may use a blood test to measure your white blood cell (WBC) count. They may order a WBC to check for or rule out other conditions that may affect your white blood cells.

Although a blood sample is the most common way to test for white blood cells, a doctor may also test other body fluids, such as cerebrospinal fluid, for the presence of white blood cells.

Below are conditions that can affect how many white blood cells a person has in their body.

It is an autoimmune condition in which the body’s immune system destroys healthy cells, including red and white blood cells.

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A number of white blood cells called CD4 T cells. When a person’s T-cell count is low

Leukemia is a type of cancer that affects the blood and bone marrow. Leukemia occurs when white blood cells are produced too quickly and cannot fight off infections.

Whether or not a person’s white blood cell count should be changed depends on the diagnosis.

If they have a medical condition that affects the number of white blood cells in their body, they should talk to their doctor about their white blood cell count goals, depending on their current treatment plan.

What Does A High White Blood Cell Count (leukocytosis) Mean?

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