How To Reduce Triglycerides In Human Body – Elevated blood triglycerides (also called hypertriglyceridemia, or HTG) increase the risk of metabolic syndrome, type 2 diabetes, and heart disease. The underlying cause of HTG is the interaction between genetic and lifestyle factors.

Those of us who have inherited risk variants in multiple pathways may be at greater risk for HTG than those who carry polymorphisms in a single pathway. Again, dietary and lifestyle changes targeting all three pathways can reduce risk. See Figure 1 , which summarizes the interactions between these pathways and the major genes conferring polygenic risk for HTG. People of East Asian and Native American descent were more likely to carry multiple risk variants in all three pathways, while people of African descent were the least likely. This is consistent with the incidence of HTG in these ethnic groups (high in East Asians, Native Americans, and Hispanics, low in African Americans).

How To Reduce Triglycerides In Human Body

1. Overproduction of triglycerides: Triglycerides (TG) in the blood can come from a variety of sources, including the food we eat, our fatty tissue, or they can be newly produced by our livers. When we consume excess energy (food), whether in the form of carbohydrates, fats, or proteins, it can be converted by the liver into fat storage. However, not all foods are equally likely to be converted into triglycerides. Simple carbohydrates (especially fructose in soda and other sugary drinks and foods) are more easily converted into triglycerides (Chiavaroli L, 2015).

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2. Impaired lipid transport: Triglycerides in the liver are packaged into VLDL lipoprotein particles and released into the blood. The LPL enzyme acts on TG, breaking it down into its basic parts so that cells can absorb them for storage (fat) or energy utilization (muscle). LPL is fine-tuned through positive and negative regulators. The APOA5 gene enhances, whereas the APOC3 gene disrupts LPL activity. Rare genetic abnormalities in this pathway increase the risk of HTG and are important contributors to cardiovascular disease (Brinton EA, 2016).

3. Underutilization of triglycerides as fuel: Triglycerides contain a large amount of energy per unit and are therefore the preferred form of energy storage. The excess food we eat is stored as fat in our adipose tissue. This is a genetically programmed process and is the basis of the “thrifty gene” principle. This principle states that our genes make it easier for us to store fat if we don’t have access to food and must rely on fuel stores. This is not too different from the widespread use of external propane tanks by people living in colder areas during the winter months when energy needs are highest. In situations of food shortage (or fasting), our bodies have systems in place that trigger the breakdown of fat stores to provide the required energy.

Table 1. Percentage of people with genetic risk variants in genes that affect triglyceride levels by geographic origin. Data comes from the 1000 Genomes Project. The underlined alleles are associated with higher triglyceride levels.

People with risk variants in the FADS1 gene may benefit from eating more foods containing long-chain PUFAs, such as fatty fish, egg yolks, poultry, and organ meats. Adequate intake of very long-chain polyunsaturated fatty acids can reduce abnormal blood lipid levels and help prevent related diseases (Wijendran V, 2004 and Lu Y, 2010 and Nakayama K, 2010). Additionally, moderate aerobic exercise is a great way to mobilize stored fat for energy.

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HealthWatch 360 can help you analyze your diet for specific nutrients, such as essential fatty acids omega-3 and omega-6, simple vs. complex carbohydrates, and more. If your doctor suspects a genetic predisposition may be the underlying cause of your abnormal blood lipid levels, we will provide genetic testing services through your doctor.

Chiavaroli L, de Souza RJ, Ha V, Cozma AI, Mirrahimi A, Wang DD, Yu M, Carleton AJ, Di Buono M, Jenkins AL, Leiter LA, Wolever TM, Beyene J, Kendall CW, Jenkins DJ, Sievenpiper JL.

Delezie J, Dumont S, Dardente H, Oudart H, Gréchez-Cassiau A, Klosen P, Teboul M, Delaunay F, Pévet P, Challet E.

Kooner JS, Chambers JC, Aguilar-Salinas CA, Hinds DA, Hyde CL, Warnes GR, Gómez Pérez FJ, Frazer KA, Elliott P, Scott J, Milos PM, Cox DR, Thompson JF.

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Lai CQ, Corella D, Demissi S, Cuppers LA, Adikonis X, Zhu Y, Parnell LD, Tucker KL, Ordovas JM.

Dietary intake of n-6 fatty acids modulates apolipoprotein A5 gene effects on plasma fasting triglycerides, residual lipoprotein concentration, and lipoprotein particle size: the Framingham Heart Study.

In the Doetinchem cohort study, dietary n-3 and n-6 ​​polyunsaturated fatty acid intake interacted with FADS1 genetic variants to influence total and HDL cholesterol concentrations.

Single nucleotide polymorphisms in the FADS1/FADS2 genes are associated with plasma lipid profiles in two Asian ethnic groups that are genetically similar but have markedly different lifestyles.

How To Optimize Your Triglycerides Levels

Pollex RL, Ban MR, Young TK, Bjerregaard P, Anand SS, Yusuf S, Zinman B, Harris SB, Hanley AJ, Connelly PW, Huff MW, Hegele RA.

Sarwar N, Sandhu MS, Ricketts SL, Butterworth AS, Di Angelantonio E, Boekholdt SM, Ouwehand W, Watkins H, Samani NJ, Salheen D, Lawlor D, Reilly MP, Hingorani AD, Talmud PJ, Danesh J.

Wang J, Ban MR, Zou GY, Cao H, Lin T, Kennedy BA, Anand S, Yusuf S, Huff MW, Pollex RL, Hegele RA.

The information on the GB HealthWatch website is for informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Never stop or delay seeking treatment because of something you read on the GB HealthWatch website. GB HealthWatch strongly recommends that you consult a qualified physician for diagnosis and answers to your personal health questions. If you think you may have a medical emergency, call your doctor or 911 immediately. With the growing prevalence of obesity, insulin resistance, and type 2 diabetes in children and adults, coronary heart disease remains the leading cause of death and disability in the United States. A 2020 study estimated that 25% of the U.S. population has elevated levels of triglycerides, a major risk factor for cardiovascular disease.

The Dangers Of High Triglycerides

A 2007 meta-analysis involving a total of 3,582 cases of fatal and nonfatal CHD showed a significant association between triglyceride values ​​and CHD risk.

Triglycerides are a type of lipid or fat in the blood. Any calories you don’t need when you eat are converted into triglycerides and stored in fat cells. Your hormones then release triglycerides between meals to provide energy.

It’s only when you take in more calories than you burn that something goes wrong with this cycle, leading to high triglycerides, also known as hypertriglyceridemia.

Triglycerides and cholesterol are different types of lipids circulating in the blood. When both are high, it is called hyperlipidemia. Triglycerides store unused calories and provide energy to the body, while cholesterol is used to build cells and produce certain hormones.

Why Are Triglycerides So Important To Metabolic Health?

High-density lipoprotein (HDL) helps remove fat from the body by binding to it in the blood and carrying it back to the liver for processing. Low-density lipoprotein (LDL) carries mainly fat and small amounts of protein from the liver to other parts of the body.

Although elevated LDL cholesterol is considered a major predictor of coronary heart disease, there is evidence that elevated triglyceride levels are also independent risk factors.

Until recently, researchers believed that high triglyceride levels were not as important as cholesterol in predicting plaque formation and heart disease, but that view has changed. Most experts now consider triglycerides to be the third important risk factor for plaque formation in the arteries, along with “good” HDL cholesterol and “bad” LDL cholesterol levels.

In fact, in studies where statins significantly lowered LDL cholesterol levels, many patients still had elevated triglyceride levels, putting them at continued risk for cardiovascular disease. This demonstrates that in addition to the critical role of LDL cholesterol in the formation of plaque within arteries (i.e., atherosclerosis), high triglycerides also play an important role.

Ways To Lower Your Triglycerides (and Cholesterol) With Lifestyle Changes

Data on the relationship between triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol and coronary artery disease risk factors are reviewed. Researchers found that among men or women with low HDL cholesterol and high triglyceride levels, smoking, diabetes, prolonged sitting, high blood pressure, and obesity were lower than those with high HDL cholesterol and low triglyceride levels. Risk groups are more common.

Hypertriglyceridemia is common in patients with type 2 diabetes because insulin plays an important role in regulating lipid homeostasis. When the body becomes resistant to insulin, organs that are sensitive to insulin regulation—such as fat tissue, liver, and skeletal muscle—cannot function properly.

Research shows that triglyceride levels help predict cardiovascular disease, a leading cause of morbidity and mortality in Western societies. Even if LDL cholesterol levels are on target, people with high triglycerides may be at significant risk for cardiovascular disease.

A 2010 study conducted by Harvard Medical School evaluated the relative contributions of triglycerides and HDL cholesterol in the risk of coronary heart disease after lowering LDL cholesterol levels. The study involved 170 cases

How It’s Made: Cholesterol Production In Your Body

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