High White Blood Cell Count With Low Platelets – Blood cell disorders are conditions that affect any blood cell: these are red and white blood cells and even platelets. All these cells are formed in the bone marrow. Although some disorders disrupt the function of one of these cells, they can also impair multiple blood cells and their specific function. .

Below are some common benign blood conditions that affect blood cells and platelets. To help our patients better understand each condition, we have included the symptoms, risk factors, means of diagnosis, and treatment options for each of these benign blood conditions.

High White Blood Cell Count With Low Platelets

What is anemia? Anemia is a blood cell disease that affects the function of red blood cells. If you have anemia, your body lacks the healthy blood cells needed to carry oxygen to the rest of the body. Anemia is also sometimes referred to as low hemoglobin. .

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The signs and symptoms related to anemia depend on the severity and type of anemia you have been diagnosed with. Additionally, anemia can sometimes present without symptoms. However, some symptoms that may be indicative of anemia include:

Anemia is often linked to a lack of specific vitamins and minerals, chronic conditions and intestinal disorders. Additionally, other risk factors for anemia include pregnancy, menstruation, age, and a family history of anemia.

To diagnose anemia, our hematologists may recommend a complete blood count (FBC), which will tell us about the level of red blood cells in your blood.

If it is due to a nutritional deficiency, supplementation of the deficient nutrients (folate, iron or vitamin B12) may be adequate. If there are other causes, treatment will need to be directed accordingly.

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Iron deficiency anemia is a common form of anemia when the body does not have enough iron to make hemoglobin.

Some common symptoms of iron deficiency anemia are general fatigue, unusual weakness, pale skin, tingling sensation in the legs, swelling and pain in the tongue, brittle nails, and frequent headaches.

Iron deficiency anemia typically results from low dietary intake, blood loss, increased iron needs during pregnancy, and reduced absorption of iron from the diet. Risk factors for iron deficiency include age, genetic conditions and lifestyle choices.

Our hematologists may recommend a series of tests to diagnose iron deficiency anemia. These tests may include a complete blood count (FBC), an iron profile, and you may need additional diagnostic tests, such as a colonoscopy and endoscopy to rule out any intestinal causes.

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Treatment options for iron deficiency anemia may include oral iron supplements, intravenous iron infusion, and red blood cell transfusion.

You can find more information about iron deficiency anemia, its symptoms, risk factors, and treatment options here.

Aplastic anemia is a rare and serious condition when inadequate blood cells are produced in the body. This causes the body to feel fatigued and can increase the risk of both uncontrolled bleeding and infections.

Some risk factors for aplastic anemia include exposure to toxic chemicals, radiation or chemotherapy in cancer treatment, certain prescription drugs, pregnancy, and autoimmune diseases.

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Treatment for aplastic anemia depends on the age and severity of the patient’s condition. The treatment aims to restore the production of blood cells. It may resolve spontaneously without treatment if the condition is mild, although this is not very common. Patients are likely to require blood and platelet transfusions to prevent and control infections.

Thalassemia is a genetic blood disorder that affects the production of red blood cells. Abnormal blood production means that affected individuals do not produce adequate amounts of functional red blood cells.

There are different types of thalassemia and the most common forms are alpha and beta thalassemia. Clinically, patients with thalassemia may present with thalassemia minor or thalassemia major.

Symptoms of thalassemia can vary, and some people have no visible symptoms, while others develop symptoms later in adolescence. Some of the most common symptoms include:

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In order to diagnose thalassemia, our hematologists may recommend a complete blood count (FBC). More specific blood tests, such as hemoglobin electrophoresis and red blood cell genotyping, are needed to clarify the diagnosis of thalassemia and determine the thalassemia subgroup.

Depending on the type of thalassemia you have been diagnosed with, treatment options may vary: Some forms of thalassemia require no treatment. However, if you need treatment, our hematologists may recommend iron chelation, blood transfusions, bone marrow or blood stem cell transplants.

Deep vein thrombosis (DVT) is a blood condition in which a blood clot (thrombus) forms in a blood vessel located deep in the body, usually in the leg or arm. This causes total or partial blockage of blood flow through the vein, causing pain, redness and swelling in the affected limb.

Various risk factors increase the chances of developing deep vein thrombosis. These include prolonged bed rest or sitting for long periods, age, overweight, smoking, cancer, heart failure, genetics, birth control pills and pregnancy.

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Ultrasound is generally used in the diagnosis of deep vein thrombosis. It allows our hematologists to check whether blood is flowing normally in the veins.

The recommended treatment is an anticoagulant, a drug that thins the blood and prevents the clot from getting bigger and rupturing, causing a pulmonary embolism. The blood clot will dissolve naturally in your body over time.

Pulmonary embolism refers to a condition in which a blood clot (thrombus) becomes lodged in a blood vessel in the lung. A PE usually begins as a clot in the deep veins (also known as deep vein thrombosis, or DVT) of the leg that breaks off and flows into the lungs. This can be a life-threatening condition if not treated quickly.

Some common symptoms of pulmonary embolism include difficulty breathing, coughing up blood, and pain in the chest or upper back.

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The most common risk factors for pulmonary embolism include hereditary conditions (blood clotting disorders), immobility for long periods, and a history of cancer or chemotherapy.

Our hematologists can order specific blood tests (including a test known as D-dimer), an ECG, a pulmonary angiography, a chest x-ray, and other diagnostic tests to diagnose pulmonary embolism.

Depending on the patient’s overall health, various treatment options for pulmonary embolism may be recommended. These include anticoagulant medications, compression stockings, and thrombolytic therapy.

You can find more information about pulmonary embolism, its treatment options, and the potential risks and side effects of anticoagulant medications here.

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Immune thrombocytopenia is an autoimmune disease that causes low platelet counts, which causes abnormal bleeding and bruising.

Patients with immune thrombocytopenia who have a platelet count above 50 may not have any signs of the disease. In these cases, the low platelet count is usually detected during a routine blood test. People with very low platelet counts may develop symptoms such as petechiae (pinprick rash), bruising, purpura (purple spots on the skin), bleeding from the nose and gums, heavy menstrual periods, and fatigue.

Some risk factors for immune thrombocytopenia include gender, which has been found to be more common in women, and diseases such as lupus and rheumatoid arthritis.

Patients with immune thrombocytopenia who have a platelet count above 50 may not have any signs of the disease. In these cases, the low platelet count is usually detected during a routine blood test.

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Patients with mild ITP usually do not require any active treatment. However, platelet counts should be monitored regularly. Treatment of ITP aims to increase platelet counts and suppress the body’s immune system to reduce platelet destruction.

First-line treatments for ITP include steroids, such as prednisolone, and intravenous immunoglobulin (IVIG). These help by dampening the immune response and preventing the destruction of platelets.

Von Willebrand disease (vWD) is one of the most common bleeding disorders that occurs due to low levels or improper functioning of von Willebrand factor (vWF) in the blood.

Symptoms of vWD can be too mild to notice or extremely severe and frequent. Symptoms can begin at any age and include lumpy bruises, blood in the urine and stool, and long-lasting bleeding. Additionally, vWD patients may notice anemia-like symptoms, such as weakness and fatigue.

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To diagnose von Willebrand disease, our hematologists may ask questions about your family history. Additionally, our doctor will check for unusual bruising and perform blood tests to determine how your blood is clotting.

There is currently no cure for vWD. However, the condition can be controlled using medications and other therapies such as antifibrinolytic agents, desmopressin, and replacement therapies.

Inherited red blood cell disorders are diseases that are passed down genetically. Two common types of inherited red blood cell disorders are sickle cell disease and thalassemia. .

A genetic mutation causes thalassemia, and these mutations hinder the normal production of hemoglobin in the body. As mentioned above, without sufficient hemoglobin, oxygen cannot be transported to the rest of the body. Without enough oxygen, your organs will not be able to function well. This can result in conditions such as an enlarged spleen, heart problems, bone deformities, and delays in both development and growth in children. .

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Treatment for thalassemia generally consists of blood transfusions and folate supplements. A stem

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