Excess Of Vitamin B12 In The Body – Vitamin B12 plays a vital role in many bodily functions. But the benefits of vitamin B12 are less discussed. In Central and South America, Mexico, the Indian subcontinent, and parts of Africa, vitamin B12 deficiency is a serious problem (1).

This vitamin significantly improves heart health, helps manage skin conditions, improves memory, and helps improve mood. The daily dose of vitamin B12 is 2.4 micrograms in adults (2).

Excess Of Vitamin B12 In The Body

From the article below, find out what it says about vitamin B12 and the benefits it offers. Also, see which foods are rich in this vitamin and the symptoms of its deficiency. Scroll down!

Why Is Vitamin B12 So Important In Pregnancy?

Vitamin B12, also known as cobalamin, helps the body’s blood cells and nerves function properly. It also plays a role in DNA synthesis (3).

The vitamin is also known for preventing megaloblastic anemia, a type of anemia that makes people weak. Studies have shown that a deficiency of this nutrient could lead to the condition (4).

Vitamin B12 is absorbed into the body in two phases. In foods, this vitamin is bound to a protein. Hydrochloric acid in the stomach separates vitamin B12 from this protein synthesis. The vitamin then combines with another protein produced by the stomach (called intrinsic factor). It is then absorbed into the body (5).

Individuals with pernicious anemia (a decrease in red blood cells) may be deficient in vitamin B12, as their bodies lack the ability to produce intrinsic factor (3).

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Vitamin B12 is important for carrying out various bodily functions. In the following section, we will discuss the crucial benefits of vitamin B12 in detail.

Vitamin B12 (along with folate) helps in the formation of red blood cells. Without enough vitamin B12, red blood cells do not divide as normally as they should and become too large. This makes it difficult for them to escape from the bone marrow (6).

This can result in fewer red blood cells in the bloodstream to carry oxygen to the body, leading to feeling tired and weak. This condition is also called pernicious anemia, and if left untreated, it can damage the brain, heart, and other organs in the body (6).

Vitamin B12 is one of the crucial ingredients during pregnancy. A deficiency of this vitamin can cause infertility and recurrent miscarriages (7).

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Starting a pregnancy with a vitamin B12 deficiency can increase the risk of neural tube defects in the newborn. It can also lead to preterm birth. Deficiency in the mother can also cause the same thing in the newborn if a sufficient amount of vitamin B12 is not available in the breast milk. However, these implications require further research (7).

Women with vitamin B12 levels below 300 ng/L have a higher risk of giving birth to babies with birth defects (8). Increasing vitamin B12 levels above this limit may reduce the risk, although more research is needed (8).

Vitamin B12 is necessary to create new maternal and fetal cells and prevent neural tube defects in the newborn (9). It works together with folate to achieve this goal. A vitamin B12 deficiency can also lead to a folate deficiency and this negatively affects pregnancy.

The vitamin can treat nausea and morning sickness, which are often associated with pregnancy. However, research in this aspect is limited.

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Vitamin B12 deficiency has been associated with changes in the skin. The most common symptom is hyperpigmentation (10).

XAn autoimmune disease that causes patchy loss of skin color due to melanin deficiency and also affects the mouth, hair and eyes. and other skin lesions

XAn abnormal change in the appearance of the skin or tissue usually caused by trauma or disease. (11), (12).

Vitamin B12 may also help treat some serious skin disorders. One study found that a vitamin B12 cream could reduce the extent and severity of eczema. This was especially true in the case of eczema in children (13).

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You can buy the cream at the pharmacy. Apply it to the affected areas twice a day. Be sure to consult your doctor. B12 also helps reduce inflammation and its side effects, which is one reason it can combat eczema.

Vitamin B12 may also help reduce the pain of shingles. Anecdotal evidence suggests that taking 1000 mcg of vitamin B12 daily may help treat the condition. However, since research is limited, we recommend that you consult your doctor before using it.

XA condition in which fat deposits under the skin causes dimpled flesh and lumps on the thighs, buttocks and stomach. , but there are limited studies to prove this.

A vitamin B12 deficiency has been observed in subjects with hair loss (15). At the base of hair follicles are tiny blood vessels that connect to the roots of each strand of hair. These blood vessels carry oxygen to the hair, thus promoting hair growth and preventing hair loss.

Persistent Elevation Of Plasma Vitamin B12 Is Strongly Associated With Solid Cancer

Vitamin B12 has shown potential for the prevention and treatment of heart disease. The nutrient lowered homocysteine ​​(a particular amino acid), high levels of which could increase the risk of ischemic heart disease (16).

B vitamin deficiencies, in general, were linked to higher homocysteine ​​levels and an increased risk of stroke (16). This could also reduce long-term costs associated with expensive medical treatments.

While there is no direct link between vitamin B12 and diabetes treatment, the nutrient may treat diabetic retinopathy (damage of blood vessels in the eyes) (18).

It may help treat diabetic neuropathy (nerve damage in the legs and feet), although more research is needed (19). Anecdotal evidence suggests that the vitamin may also treat some of the symptoms of neuropathy, including numbness, pain, and tingling sensations.

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Even more interesting is that metformin, a drug commonly prescribed for diabetics, can cause a vitamin B12 deficiency (21). This is why it might be a good idea to supplement it, especially in case of diabetes. Pernicious anemia is the vitamin B12 deficiency found in type 1 diabetes (22).

Low plasma levels of vitamin B12 have been linked to lower bone mineral density in humans. Studies suggest that the vitamin may affect bone formation. It has also been linked to osteoblastic (bone formation) activity (23).

XA bone disease that makes bones weak and fragile due to low bone mineral density and decreased bone mass. (24). Since vitamin B12 helps reduce homocysteine ​​levels, it may play a beneficial role in this case.

In a study of older women, lower levels of vitamin B12 were linked to greater hip bone loss (25).

Vitamin B 12: How Much Is Too Much?

Age-related macular degeneration has been associated with reduced plasma levels of vitamin B12 and increased levels of homocysteine. Taking vitamin B12 supplements can prevent the condition (26). However, more in-depth studies are needed to understand the mechanism.

Another study also states that high levels of homocysteine ​​may increase the risk of age-related macular degeneration (27). Because vitamin B12 helps lower levels of this amino acid, it could be useful in treating AMD.

In another study of women, daily supplementation with folic acid, vitamin B12, and vitamin B6 over a seven-year period was found to reduce the risk of age-related macular degeneration (28).

Studies show that supplementing with vitamin B12 along with antidepressants can improve depressive symptoms. Vitamin B12 deficiency may be associated with depression (29).

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Adequate levels of vitamin B12 can also increase the likelihood of recovery from depression. However, we need further studies to confirm this finding (30).

The vitamin may also have a beneficial effect on mood. The vitamin is believed to produce chemicals in the brain responsible for better mood stabilization, although more research is needed to understand the mechanism. Anecdotal evidence suggests it may help treat stress and some anxiety disorders.

Vitamin B12, when combined with omega-3 fatty acids, may also slow memory decline in adults. The nutrients improve cognitive function and even slow the progression of mild cognitive impairment (31).

Another study claims that the vitamin can prevent brain volume loss in older adults. Individuals who took adequate amounts of vitamin B12 had a reduced risk of brain shrinkage/atrophy (32).

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XA progressive neurodegenerative disease that causes impaired memory and mental functioning due to shrinkage of brain cells. , although further studies are needed to understand the mechanism (33), (34).

Because vitamin B12 also helps cell production (a process called methylation), it may help improve symptoms of autism.

XA serious developmental disorder that affects an individual’s overall cognitive, emotional, and social ability to interact. (35).

Vitamin B12 plays a role in cellular energy production (36). However, there is no research that says it can increase energy levels or improve athletic performance, as is commonly believed.

B12 Shots: Vitamin B12 Injections Benefits, Uses, Risks

Research on this aspect is limited. However, one study states that adequate levels of vitamin B12 can improve sleep-wake rhythm disorders (38). This study was only conducted on two patients, so larger studies are needed to understand the impact this vitamin may have on sleep quality.

It is believed that a vitamin B12 deficiency can cause insomnia. However, more research is needed to establish the link.

XA disorder characterized by widespread musculoskeletal pain and tenderness, accompanied by fatigue, impaired sleep, and mood problems. and chronic fatigue syndrome. There is a lack of research in this aspect.

One study claims that vitamin B12 injections can work as an analgesic, thus aiding in the treatment of fibromyalgia (39).

Vitamin B12 And Diabetes

Other research

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