What Is The Function Of Vitamin B12 – Vitamin B12 is a compound necessary for human health. If you’re not getting enough B12 levels, there’s a good chance you won’t feel as good as you could. Understanding the role of B12 in our bodies, the common forms found in foods and supplements, and the associated health benefits can help ensure optimal health.
Vitamin B12 describes several different cobalt-containing compounds. Together these are known as cobalamins. Vitamin B12 helps our body produce new cells, protects and repairs nerves, and plays an important role in early childhood brain development.
- 1 What Is The Function Of Vitamin B12
- 1.1 Amazon.com: Naturewise Vitamin B12 1,000 Mcg For Mental Clarity & Cognitive Function Energy Support For Maximum Vitality And Wellbeing B12 (360 Softgels)
- 1.2 How Much Vitamin B12 Should I Take?
- 1.3 The A List For Vitamin B 12 Sources
- 2 Nature Made® Vitamin B12 500mcg Tablets 100ct.
- 3 Vitamin B12 (cyanocobalmin)
What Is The Function Of Vitamin B12
Vitamin B12 may be called cobalamin, methylcobalamin, cyanocobalamin, adenosylcobalamin, hydroxocobalamin, or a few others. Cyanocobalamin is a synthetic form that does not occur naturally in the human body. Studies suggest that supplementing with bioidentical forms provides the best absorption (R). Curiously, synthetic cyanocobalamin (linked with cyanide) appears to be the preferred form for dietary supplementation (R).
Amazon.com: Naturewise Vitamin B12 1,000 Mcg For Mental Clarity & Cognitive Function Energy Support For Maximum Vitality And Wellbeing B12 (360 Softgels)
Source: Paul C, Brady DM. Comparative bioavailability and use of specific forms of B12 supplementation with the potential to mitigate B12-related genetic polymorphisms. Integr Med (Encinitas). 2017;16(1):42–49.
Little research suggests that all natural forms, especially adenosicobalmin and methylcobalamin, are equally well absorbed ( R )( R ). Limited human studies have shown that sublingual and oral (taken as pills) are almost equally well absorbed. (R).
I’ve heard that vitamin B12 is better absorbed orally, through liquids, sprays, or sublingual tablets (dissolved under the tongue). This may be especially true for those with genetic mutations or digestive disorders that affect cobalamin absorption. I haven’t seen any convincing studies showing that the same could be said for the majority of people.
Vitamin B12 is absorbed by cobalamin through very specific pathways. It is first broken down in the stomach, absorbed through the intestines, transported through the bloodstream and absorbed into the cells. Each step of this process contains cobalamin-specific compounds such as
A Schematic Representation Of Mechanism: ‘how Vitamin B12 Regulates…
Mutations in the TC (TCN1) gene limit the amount of absorbed cobalamin. This can be particularly difficult to detect because it does not affect the amount of cobalamin measured in the bloodstream (R). The associated SNPs are rs526934 and rs34324219.
Vitamin B12 plays a crucial role in many aspects of human health and is essential for optimal health. A B12 supplement does not guarantee any special benefits, but a deficiency will almost certainly have a negative effect on health and well-being. Below are some of the benefits of vitamin B12.
Vitamin B12 is necessary for the formation of new red blood cells. B12 deficiency can cause red blood cells to develop inappropriately. This usually results in larger-than-normal red blood cells that cannot move from the bone marrow to the bloodstream at the appropriate speed (R).
This is measured by the MCV (Mean Corpuscular Volume) test, which is common to most blood panels. Higher MCV values indicate a larger mean red blood cell size. This is one indicator used to diagnose vitamin b12 deficiency along with other health conditions such as certain infections, kidney disease, liver disease or HIV.
How Much Vitamin B12 Should I Take?
Vitamin B12 plays a crucial role in brain development. Young children are especially susceptible to b12 deficiency, and low levels can lead to stunted brain growth (R). In addition, low B12 levels in early childhood have also been linked to higher risks of depression in adulthood (R).
Folate (folic acid, vitamin B-9), which is often recommended during pregnancy, is also largely responsible for brain development and later cognitive function. Vitamin B12 is a necessary additional factor in the production of tetrahydrofolate (activated folic acid). There is solid research showing the beneficial effect of folate supplementation and its effect on B12 levels during pregnancy ( R )( R ).
Many of the case studies I’ve read that called for urgent B12 therapy involved infants. These cases typically involve children who have been fed a b12-deficient diet (usually vegan). In most cases, short-term IV therapy seems to fix things within a few months.
There is strong scientific evidence to support the fact that vitamin B12 deficiency is associated with lower bone density ( R )( R ). Elderly people and women are particularly susceptible to bone-related diseases.
The A List For Vitamin B 12 Sources
Studies of these populations have highlighted the extreme relationship between B12 levels and bone disease. Although there is a lot of evidence, the exact nature of the relationship between vitamin B12 and bone health remains unclear.
Leading theories suggest that the problem is related to the formation of new bone-forming cells known as osteoblasts (R).
Vitamin B12 has long been considered to play a key role in metabolism and cellular energy production. It is needed for folate metabolism, methionine production and ubiquinone synthesis (R). Recent studies have only strengthened the role of B12 in metabolism.
Recent laboratory studies identified more than 40 microbial proteins and enzymes that were B-12 dependent. This is much more than previously recognized and suggests that B12 is heavily utilized by microbial communities.
Nature Made® Vitamin B12 500mcg Tablets 100ct.
Chronic B12 or folate deficiency has been linked to lower energy levels and athletic performance (R). However, I have not seen overwhelming science to suggest that those with adequate levels of B12 receive any special energy benefits from B12. That is; Taking B12 may not give you an energy boost if you’re already getting enough.
The role of vitamin B12 in cardiovascular health is complex. There are studies showing that lower levels of vitamin B12 are associated with a higher risk of certain vascular diseases ( R ).
Association between vitamin B12 deficiency and cardiovascular health (R)(R). To complicate matters, some claim that some report
In many processes. Immediate symptoms are often characterized by fatigue and weakness, while chronic deficiency can cascade into immune system dysfunction, memory loss, and even neuropathy ( R )( R )( R ). Below are the symptoms that are usually caused by b12 deficiency:
Timing Of Folic Acid/vitamin B12 Supplementation And Hematologic Toxicity During First‐line Treatment Of Patients With Nonsquamous Non–small Cell Lung Cancer Using Pemetrexed‐based Chemotherapy: The Pemvitastart Randomized Trial
A 2015 paper published by EFSA’s Panel on Dietary Products reviewed eight separate studies on vitamin B12, ranging from 1.5 to 3.0 micrograms per day. The average dose is calculated to be 2.2375 mcg/day (PDF).
This is slightly less than the 2.4 micrograms/day recommended by the US Dietary Reference Intake for vitamin B12 (R) for men and women aged 18-50. There is currently no tolerable upper limit for b12.
There is no tolerable upper intake (UL) for vitamin B12 because it is considered relatively safe at almost any dose. The RDA is 2.4 micrograms per day, although I have seen (and taken) supplements that contain 5000 micrograms per serving. I took one of them every day for a year and had no problems. Also the b12 levels went up quickly!
However, B12 doses are all smiles and sunshine. Studies show that b12 supplementation can have a negative effect on certain health problems. In particular, it can have negative effects on those with diabetic neuropathy ( R ).
Vitamin B12 (cyanocobalmin)
Curiously, many cases of early childhood b12 deficiency report adverse reactions. When b12 is given, the general deficiency symptoms begin to disappear, but unexplained muscle twitching and spasms appear. from
With a limited number of case reports on the subject, this problem seems to be resolved within a few weeks or months. In some cases, these seizures have been reported to be severe enough to require anticonvulsant medication (R).
This publication covers the research and data used to determine the RDA, EAR, and AI for vitamin B12. These are the numbers that many doctors and/or nutritionists refer to.
There is no doubt that vitamin B12 is one of the most important compounds for maintaining optimal health. Whether your body is producing energy, squeezing new blood cells, or working your brain overtime, B12 plays an important role. I also recommend reading our supplement buyer’s guide
What Is Vitamin B12 Good For? Energy, Health Benefits Explained
If you are considering taking a vitamin B12 supplement. Between these two resources, you should be able to get a good idea of how to find a good brand, as well as some personal recommendations.
Health nut and supplier of Optimus Medica. Spends his time researching chronic diseases, nutritional therapies, computer science and design. She can be found taking notes and getting inspiration from Mother Nature when she’s not working. Define vitamin B12 Discuss the functions of vitamin B12 Discuss the causes of vitamin B12 deficiencies Identify groups at risk for vitamin B12 deficiency Discuss the recommended B12 diet Identify the best natural sources of B12 Determine the dosage and safety of B12 supplements This presentation aims to explore the biological and psychological effects of vitamin B12 functions; discuss the causes, symptoms and effects of vitamin B12 deficiency; identify populations at risk for B12 deficiency; discuss the Recommended Dietary Allowance (RDA); determine dosage and safety factors of B12 supplementation; and identify the best natural sources of vitamin B12.
3 What is vitamin B12? Vitamin B12 is one of the 13 essential vitamins that the body needs to function. The properties of B12, also known as cyanocobalamin, are: Water-soluble (dissolves in water) Only produced by microorganisms (e.g. bacteria) Can be stored by the body in the liver Found naturally in animal food Can’t be produced by animals and plants Synthetically added to plant nutrients (fortified) Essential vitamins are organic compounds (containing carbon) that are essential for body functions; however, the body cannot produce them, so these vitamins must be obtained from food, naturally from animal products, and added synthetically to plant-based food sources. Although vitamin B12 can be stored in the liver for years, it is water soluble and unused amounts can be eliminated through the urine (Medline Plus, 2015). Only a single-celled microorganism
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