What Is The Cause Of Fatty Liver In Humans – Steatous liver disease (SLD) involves the presence of excess fat in the liver. Metabolic conditions and heavy alcohol use are risk factors. Depending on the type of SLD you have, fat accumulation may not cause problems, or it may lead to liver damage. You can often prevent or even reverse SLD with medication and lifestyle changes.
Steatous liver disease (SLD) includes several conditions associated with steatosis in the liver. “Steatosis” is a term health care providers use to describe the accumulation of fat in an organ (usually your liver). A healthy, well-functioning liver contains little fat. Fat accumulation becomes a problem when it reaches more than 5% of the liver’s weight.
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What Is The Cause Of Fatty Liver In Humans
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Previously, steatotic liver disease was known as “fatty liver.” In 2023, experts renamed the condition and its subcategories to more accurately reflect its causes. For example, while some conditions related to the composition of your body fat (such as obesity) can increase your risk of steatosis, there are several risk factors that are not related to weight or body mass index (BMI).
In ALD, steatosis occurs due to excessive alcohol consumption. Every time your liver filters alcohol, some of its cells die. Normally, your liver can produce new cells to replace the old ones, so there’s no problem. But if you drink too much alcohol, your liver may not be able to cope. Instead, steatosis may occur.
Healthcare providers previously referred to MASLD as non-alcoholic fatty liver disease (NASLD) because steatosis is not associated with heavy alcohol consumption. Experts renamed the condition to reflect the accumulation of fat in the liver
Associated with. In MASLD, the culprit is cardiometabolic risk factors. These factors include conditions and characteristics that pose a risk to your heart health.
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The MASLD also applies if you consume small amounts of alcohol per week. “Small amounts” means less than 140 grams per week for people identified as female at birth (AFAB) and less than 210 grams per week for people identified as male at birth (AMAB). For reference, in the US, one standard, 12-oz. beer contains about 14 grams of alcohol.
Metabolic-associated steatohepatitis (MASH) is a serious form of MASLD. In MASH, fat accumulation progresses to inflammation, then tissue damage and scarring (fibrosis). Healthcare providers previously called MASH non-alcoholic steatohepatitis (NASH).
If you have MetALD, metabolic risk factors and alcohol consumption play a role in the accumulation of fat in the liver. With MetALD, you have a cardiometabolic risk factor and consume more than 140 grams per week (AFAB) or more than 210 grams per week (AMAB).
What contributes most to the accumulation of fat in the liver (alcohol consumption or metabolic risk factors) varies from person to person.
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SLD may result from causes other than alcohol use or cardiometabolic risk factors. For example, various drugs and diseases can cause steatosis. Sometimes healthcare providers cannot identify a specific cause. SLD without a clear cause is called cryptogenic SLD.
That’s why it’s so important to learn what causes liver fat to build up and treat yourself. Even if you have early stage cirrhosis, there are steps you can take to protect your liver from further damage. In some cases, you can even repair some damage by following your provider’s treatment plan for you.
More often, people notice symptoms after SLD progresses to cirrhosis of the liver. When cirrhosis develops, you may experience:
SLD has multiple causes. However, you are more likely to develop SLD if you have a cardiometabolic risk factor, if you consume unhealthy amounts of alcohol, or both.
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Without treatment, steatotic liver can progress to cirrhosis of the liver, which can lead to liver failure, liver cancer, and cancer outside the liver. People with MASLD are also at increased risk of heart disease. Heart disease—not liver disease—is the leading cause of death in people with MASLD.
Because SLD usually causes no symptoms, your healthcare provider may be the first to notice a problem. High levels of liver enzymes that show up in a blood test for other conditions can raise a red flag. Elevated liver enzymes are a sign that your liver is damaged.
There is no specific treatment or medication. Instead, providers focus on helping you manage the risk factors that contribute to the condition. This includes lifestyle changes that can improve your health.
Depending on the severity of your condition, it is possible to get rid of SLD and even some scarring. Your liver has an amazing ability to repair itself. If you follow your provider’s treatment plan, it is possible to reduce liver fat and inflammation. You can prevent the damage from getting worse and in some cases reverse early liver damage.
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SLD does not cause major problems for most people unless they develop advanced cirrhosis. Many people with SLD have a normal life expectancy.
Untreated cirrhosis of the liver eventually leads to liver failure or liver cancer. Your liver is an organ you cannot live without. That’s why it’s so important to protect your liver if you find out you have SLD.
If your SLD is weight-related, follow a balanced diet to lose weight slowly but steadily. Health care providers often recommend avoiding sugar and trying the Mediterranean diet, which is rich in vegetables, fruits and good fats. Other foods and diets rich in nuts, seeds, whole grains, and fish and chicken are helpful food choices for SLD. It’s also important to avoid eating too much red meat or drinking sugary drinks.
Consider steatotic liver disease a warning sign that can help you take steps to avoid fatal liver disease such as cirrhosis or liver cancer. Having too much fat in your liver is not the same as scarring – which is much more serious. Work with your healthcare provider to find out if you are at risk for developing inflammation or scarring of the liver. If you are, focus on managing causes and contributing factors, including alcohol use and metabolic syndrome. You can take steps to protect your liver, improve your health, and even potentially save your life. The liver normally contains some amount of fat, but excessive accumulation can cause fatty liver disease. A fatty liver can reduce liver function and cause pain, weight loss, fatigue, and bloating in the abdomen or abdomen.
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Doctors sometimes call fatty liver disease the silent disease. This is because a person may not experience any symptoms even as the disease progresses.
However, fatty liver disease can enlarge the liver. When this happens, it can cause pain or discomfort in the upper right part of the abdomen, which is the area between the thighs and chest.
There are two types of fatty liver disease—non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease.
Separate conditions fall under the umbrella of NAFLD: simple fatty liver or non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH).
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A person who has developed NASH has inflammation and damaged liver cells, as well as fat in the liver.
People who drink alcohol excessively can develop alcoholic fatty liver disease. As the liver breaks down excess alcohol, it can generate harmful substances.
This is the first stage of alcohol-related liver disease, and if a person stops drinking alcohol, they may be able to reverse it.
Cirrhosis is the most serious stage of liver disease. It usually occurs when scarring replaces healthy liver tissue. It can lead to liver failure.
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High levels of fats in a person’s blood, such as high cholesterol and triglycerides, can also contribute to the risk of developing fatty liver disease.
Experts consider a person’s blood triglyceride level to be high if it is above 150–199 milligrams per deciliter (mg/dL).
Causes of fatty liver disease include hepatitis C infection, rapid weight loss, and certain medications, including diltiazem and glucocorticoids.
The liver breaks down alcohol and removes it from the body. As alcohol breaks down, it releases harmful toxins that can damage liver cells and cause inflammation.
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There are currently no drugs to treat NAFLD. However, depending on the stage of the disease, some people can reverse it.
However, losing weight too quickly can make NAFLD worse. A healthy way to gradually lose weight is with a balanced diet and regular exercise.
People who have alcoholic fatty liver disease may be able to reverse the liver damage and inflammation or prevent it from getting worse by not consuming alcohol. However, this will not reverse cirrhosis.
Some people may find giving up alcohol extremely difficult, but a doctor can advise on how to do so in a safe and supportive way.
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Foods that may help prevent the development of NAFLD include garlic, coffee, leeks, asparagus and probiotics. One should choose whole grains and eat a wide range of fruits and vegetables.
, simple sugars, red meat, processed food, and low-fiber foods can lead to the development of NAFLD.
Exercise per week. This should be an activity that raises your heart rate, such as cycling.
It can be difficult for a person to know when to seek medical advice because fatty liver disease often has no symptoms.
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Doctors will consider a person’s medical history, diet, and lifestyle habits. They will
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