What Is Normal Platelet Count By Age

What Is Normal Platelet Count By Age – Dysmorphic uterus: Obstetric outcomes after hysteroscopic office metroplasty in patients with infertile and recurrent pregnancy loss. A prospective observational study

Open Access Policy Institutional Open Access Program Guidelines for Special Topics Editorial Process Research and Publication Ethics Fees for Processing Articles Fees Opinions

What Is Normal Platelet Count By Age

What Is Normal Platelet Count By Age

All articles published by are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by , including figures and tables. For articles published under a Creative Common CC BY open access license, any part of the article may be reused without permission, provided the original article is clearly cited. For more information, please see https:///openaccess.

Clinical Characteristics And Responses Of Itp Patients Platelet…

Feature papers represent the most advanced research with significant potential for major impact in the field. A Feature Paper should be a substantial original article that involves multiple techniques or approaches, provides an outlook for future research directions, and describes possible research applications.

Feature papers are submitted by individual invitation or recommendation from the scientific editors and must receive positive feedback from the reviewers.

Editor’s Choice articles are based on recommendations from scientific editors of journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be of particular interest to readers or important in the respective research area. The aim is to provide a snapshot of some of the most exciting works published in the journal’s various research areas.

By Wolfgang Hermann Wolfgang Hermann Scilit Preprints.org Google Scholar See Publications 1 , Lorenz Risch Lorenz Risch Scilit Preprints.org Google Scholar See Publications 1, 2, 3 , Chris Grebhardt Chris Grebhardt Scilit Preprints.org Google Scholar See Publications 4 , Urs E. Nydegger Urs E. Nydegger Scilit Preprints.org Google Scholar See publications 5 , Benjamin Sakem Benjamin Sakem Scilit Preprints.org Google Scholar See publications 5 , Mauro Imperiali Mauro Imperiali Scilit Preprints.org Google Scholar See publications 6 , Harald Renz Harald Renz Scilit Preprints. org Google Scholar See publications 7 and Martin Risch Martin Risch Scilit Preprints.org Google Scholar See publications 8, *

Current Status Of Research On Osteoporosis In Copd: A Systematic Review

Department of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, University Hospital Giessen and Marburg, Baldingerstraße, 35043 Marburg, Germany

Submission received: August 19, 2020 / Revised: August 27, 2020 / Accepted: September 1, 2020 / Published: September 3, 2020

Currently, age- and sex-independent reference limits (RLs) are often used to interpret platelet counts in seniors. We aimed to define and validate reference intervals (RIs) for platelet counts in the context of the prospective SENIORLAB study. Subjectively healthy Swiss individuals aged 60 years and older were prospectively enrolled and followed for morbidity and mortality. Participants who had conditions known to affect platelet count were excluded. The obtained RIs were validated with indirect statistical methods. Frequencies of abnormal platelet counts in a population-based setting, including 41.5% of the entire age-specific population of the Principality of Liechtenstein, were compared using age- and sex-independent RIs and the RLs obtained in this study. For men (n = 542), 95% RIs for platelet counts were defined as follows: 150–300 × 10

What Is Normal Platelet Count By Age

/L (80 years and over). For women (n = 661), the pooled age-independent 95% RI was 165–355 × 10

Namık Kemal Tıp Dergisi

/L. These RI values ​​were validated by indirect RI determination of 51,687 (30,392 female/21,295 male) age-matched patients. Age- and sex-independent RIs showed unbalanced frequencies of abnormal platelet counts between the two sexes, which were corrected by introducing age- and sex-specific RLs. In conclusion, women have higher platelet counts than men. While the upper RL for men remains constant, the lower RL decreases with age. We propose to abandon the practice of using sex- and age-independent RL for platelet counts in the elderly.

Platelets, the smallest circulating blood cells, are produced in the bone marrow and play a crucial role in hemostasis, but also have extrahemostatic functions [1, 2]. There are many causes of altered platelet count, which can manifest as either thrombocytopenia or thrombocytosis [3, 4, 5]. Thrombocytopenia or thrombocytosis can occur as an imbalance between platelet production in the bone marrow, consumption in the peripheral tissue and platelet distribution in the organs [3, 6]. While no circumstances are known to increase platelet lifespan (unlike, for example, red blood cells), platelet lifespan is shorter under conditions of increased platelet consumption [3].

Primary thrombocytosis is caused by myeloproliferative neoplasia and other bone marrow disorders, whereas secondary thrombocytosis can occur due to metabolic disorders (e.g. iron deficiency), infections and chronic inflammation (e.g. tuberculosis, chronic inflammatory bowel disease), post-traumatic disorders, surgery (e .with significant blood loss, injuries) or hyposplenism or in association with paraneoplastic disease in patients with metastatic cancer or in regenerative thrombocytosis (eg after chemotherapy, hemolytic disease) [3].

Thrombocytopenia can occur due to increased consumption, e.g. in the context of side effects, immune-mediated thrombocytopenia (eg, ITP or post-transfusion purpura), thrombotic microangiopathy (eg, liver enzyme levels, low platelet count) syndrome), secondary to underlying disease (eg, lupus erythematosus, lymphoma, malaria), or in mechanical heart valves [3]. Other mechanisms lead to decreased production of genetic disease, viral infection (e.g. Parvovirus, human immunodeficiency virus, cytomegalovirus), bone marrow damage (e.g. by chemotherapy, radiation, immunosuppression), vitamin deficiency (e.g. vitamin B12, folic acid), bone marrow infiltration (eg in leukemia, lymphoma, carcinoma) and aplastic anemia as well as abnormal distribution, such as in splenomegaly or pseudothrombocytopenia due to dilution in pregnancy [3, 7]. Taken together, platelet count abnormalities are a symptom rather than a disease and can be observed in a wide variety of medical and surgical conditions, some of which have a high frequency among seniors. Abnormal platelet counts can therefore be considered an early indicator of undetected occult disease or a predictor of outcome in established disease [8, 9, 10, 11].

American Journal Of Hematology

Platelet counts are mainly ordered for two reasons. First, the parameter to assess bleeding risk is determined depending on the underlying disease and other factors [12]. In immune thrombocytopenia, the platelet count is less than 20 or 30 × 10

/L has been suggested to be associated with an increased risk of bleeding [13, 14]. Second, platelet counts below or above reference limits may indicate underlying disease. If these reference limits are inaccurate, the diagnosis of the underlying disease may be missed with potential adverse patient outcomes (eg, delayed diagnosis with delayed treatment). To make decisions as accurately as possible, decision limits (defined as the upper and lower limits of the reference interval) for the diagnosis of thrombocytopenia and thrombocytosis must be as accurate as possible. With regard to platelet counts, there is no clear position on whether platelet count reference intervals should be age- and sex-specific. While some authors suggest stratification according to gender, age or other characteristics [15, 16, 17, 18, 19, 20], gender- and age-independent reference intervals are commonly used in clinical practice [21, 22, 23, 24 , 25] . The importance of having accurate reference ranges for platelet counts available has been evident for a long time [26]. As conditions associated with thrombocytopenia or thrombocytosis occur relatively frequently in seniors, and as reference intervals for seniors are generally not well described, we determined reference intervals for platelet counts in seniors within the framework of the SENIORLAB study [27]. This was done because there is a lack of data on patients older than 70 years and the studied groups were quite small. Such an approach to determining reference intervals in a study where study participants have been recruited for this purpose is technically called a direct method of reference interval determination [28]. We further validated our results with a different statistical approach in an independent setting of clinical patients. An approach to determining reference intervals in a study where reference intervals are estimated from patient outcomes is technically called an indirect method of reference interval determination [28]. Finally, we compared the frequency of abnormal platelet counts using modified and conventional platelet count reference intervals in a population-based setting.

The present analysis was performed within the framework of the SENIORLAB study, a prospective cohort study for which the detailed study protocol has been published elsewhere [27]. Briefly, the SENIORLAB study includes 1467 subjectively healthy individuals seen between May 2009 and December 2011 at a baseline visit to obtain a detailed history, anthropometric data, and blood by venipuncture under optimal preanalytical conditions. From December 2013 to December 2014, study participants were followed up for mortality and morbidity with a 100% follow-up rate. For the present analysis, we included participants aged 60 years and older who lived in Switzerland and were in a fasting state at the baseline examination. An additional inclusion criterion, as previously proposed as an objective indicator of health in seniors, was survival. Because life expectancy in seniors varies by age, we deliberately chose the following minimal survival criteria for exclusion from the present analysis: death before first follow-up for participants < 80 years, death within at least 3 years between 80 and 85 years, death within at least 2 years between 85 and 90 years and death within at least 1 year for age 90 and older. Additional exclusion

What Is Normal Platelet Count By Age

Normal blood platelet count by age, normal platelet count by age dengue, normal platelet count by age 20, male normal platelet count by age, normal platelet count by age 10 years, female normal platelet count by age chart, normal blood platelet count, platelet count normal range by age, what is the normal platelet count by age, normal platelet count by age pediatrics, normal platelet count by age chart, normal platelet count by age

Related posts

Leave a Reply

Your email address will not be published. Required fields are marked *