What Is Low White Blood Cells Mean – Leukopia (from Greek λευκός (leukos) “white” and πενία (pia) “deficiency”) is a decrease in the number of leukocytes (WBC). They are found in the blood, are the white blood cells and represent the body’s primary defense against infection. Therefore, people with leucopia are at increased risk of infection.

Neutropia, a subtype of leukopia, refers to a decrease in the number of circulating neutrophils, the most abundant white blood cells. The terms leukopia and neutropia may sometimes be used interchangeably because neutrophil count is the most important indicator of infection risk. Agranulocytosis is an acute form of neutropia.

What Is Low White Blood Cells Mean

What Is Low White Blood Cells Mean

A low white blood cell count can be due to acute viral infections such as a cold or flu. It is associated with chemotherapy, radiation therapy, myelofibrosis, aplastic anemia (failure to produce white blood cells, red blood cells, and platelets), stem cell transplant, bone marrow transplant, HIV, AIDS, and steroid use.

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Other causes of low white blood cell count include systemic lupus erythematosus, Hodgkin’s lymphoma, some cancers, typhoid, malaria, tuberculosis, Dgue, rickettsial infections, spleen enlargement, folate deficiency, psittacosis, sepsis, Sjögr’s syndrome and Lyme disease. It has also been shown to be caused by a deficiency of certain minerals such as copper and zinc.

Pseudoleukopia may develop at the beginning of an infection. The leukocytes (mainly neutrophils, which respond first to injury) begin to migrate toward the site of infection where they can be scanned. Their migration causes the bone marrow to produce more leukocytes to fight infection and restore leukocytes in the bloodstream. However, because the blood sample is taken at the beginning of the infection, it contains only small amounts of leukocytes, which is why it is called “pseudoleucopy”.

Medications that can cause leucopia include clozapine, an antipsychotic with a rare side effect that results in complete abscesses of all granulocytes (neutrophils, basophils, eosinophils). The antidepressant and drug used to treat smoking addiction, bupropion HCl (Wellbutrin), can also cause leucopia with long-term use. Minocycline, a commonly prescribed antibiotic, is another drug known to cause leucopia. There are also reports of leukopia caused by divalproex sodium or valproic acid (Depakote), a drug used to treat epilepsy (seizures), mania (with bipolar disorder), and migraines.

The FDA monograph on metronidazole states that this drug may also cause leukoscopy, and the prescriber’s information suggests the need for a complete blood count, including differential cell count, particularly before and after high-dose therapy.

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Leucopia is a known complication of immunosuppressants such as sirolimus, mycopholate mofetil, tacrolimus, ciclosporin, leflunomide and TNF inhibitors.

Chemotherapy targets fast-growing cells such as tumors, but it can also affect white blood cells because they are marked as fast-growing in the bone marrow.

A common side effect of cancer treatment is neutropia, the reduction in the number of neutrophils (a type of white blood cell).

What Is Low White Blood Cells Mean

The 2.5 perctile (right interval boundaries in the image, showing 95% prediction intervals) is a common limit for defining leukocytosis. DEAR MAYO CLINIC: My 16-year-old granddaughter was recently diagnosed with a low white blood cell count after visiting the emergency room twice with migraines, vomiting, and temporary vision loss. What could be causing a low white blood cell count in someone her age? I’m worried it’s something serious and wondering what further tests should be done.

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ANSWER: Many diseases and conditions can lead to low white blood cell counts. Without more information, it is difficult to say what the specific cause of your granddaughter’s situation might be. The low number is unlikely to be related to her migraines and other symptoms. It would be advisable to do another blood test to see if the problem persists. Your doctor can then decide whether further testing is necessary.

Blood consists of several components. In addition to white blood cells that fight infection, red blood cells carry oxygen and platelets help blood clot. Bone marrow, the spongy tissue in bones, makes blood cells.

There are different types of white blood cells. Neutrophils fight fungal and bacterial infections. Lymphocytes protect the body from viral infections. Monocytes help get rid of dead or damaged tissue and regulate the body’s immune response. Eosinophils are disease-fighting white blood cells. Basophils play a role in wound healing, infections and allergic reactions.

One of the most common causes of low white blood cell counts is a viral infection. These infections can sometimes temporarily disrupt the production of blood cells in the bone marrow, causing the number of blood cells to decrease. Levels typically rise again as the body recovers from the infection. For most people, this temporary drop in blood cells has no long-term effects.

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Certain medications can also cause low white blood cell counts because they can destroy white blood cells or damage the bone marrow. For example, taking antibiotics can sometimes cause an abnormal drop in neutrophils, a condition called neutropenia. With this in mind, it would be wise for your granddaughter’s doctor to have any medications she is taking checked to see if they could be causing changes in her blood cell count.

A variety of other diseases and disorders can also lead to neutropenia. For an overview of this condition and more details about diagnosis and treatment, see a video from the Mayo Clinic.

The list of other possible causes of a person’s white blood cell drop is long. Autoimmune diseases, congenital diseases that affect bone marrow function, spleen diseases, certain infectious diseases, cancer, and parasitic diseases, among others, can lead to low white blood cell counts.

What Is Low White Blood Cells Mean

A good next step for your granddaughter would be to have a complete blood work done. This test measures the components in the blood. The specific type of white blood cell count that this test shows to be low in your granddaughter, as well as the results of the other blood component measurements, may provide insight into what may be causing the decline.

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The other symptoms you mentioned—headache, vision loss, and vomiting—should also be addressed through a physical exam, a review of your granddaughter’s family and medical history, and any additional tests her doctor recommends. Even if these symptoms are not related to the decrease in their white blood cells, it is important to investigate and identify the underlying cause. — Carola Arndt, M.D., Pediatric Hematology/Oncology, Mayo Clinic, Rochester, Minnesota.

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ROCHESTER, Minn. – Despite having a record year for organ donations in the U.S. last year, an estimated 17 people die every day while waiting for a… White blood cells, also called leukocytes, make up less than 1% of your blood cells, but are very important for health and protection against disease. These are the cells that defend the body against viruses and bacteria. A low or elevated white blood cell count can indicate a number of disorders in the blood and bone marrow.

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A low white blood cell count is sometimes called leukopenia (or leukocytopenia). The number of white blood cells varies from person to person.

The normal range is usually between 4,000 and 11,000 white blood cells per microliter of blood. Anything below 4,000 is usually considered a low white blood cell count.

A low white blood cell count is often caused by problems with the bone marrow where they are made. Bone marrow is the spongy tissue inside bones that is responsible for producing most of the body’s blood cells.

What Is Low White Blood Cells Mean

Certain cancers, such as leukemia, and treatments such as chemotherapy can affect the bone marrow’s ability to produce white blood cells. Chemicals such as benzene and certain pesticides can also damage the bone marrow.

Normal White Blood Hi Res Stock Photography And Images

Another common cause of low white blood cell count is infection. An infection can affect the bone marrow and make it difficult for the body to produce white blood cells. Additionally, when the body is fighting a particularly severe infection, the rate of white blood cell production, even if increased in response, may not be able to keep up with the rate at which white blood cells are being used to fight the disease.

Other causes of leukopenia include autoimmune diseases such as lupus and rheumatoid arthritis, which cause the body to attack its own white blood cells. Certain medications can also destroy white blood cells. Vitamin deficiencies, excessive alcohol consumption and generally poor nutrition can also reduce the number of white blood cells.

Abnormally low levels of white blood cells can lead to a higher risk of any type of infection. A low white blood cell count itself does not directly cause symptoms, but a patient who is immunocompromised due to significant leukopenia and then develops an infection may experience symptoms associated with that infection, such as: B. Fever, local pain, fatigue, muscle pain, loss of appetite and general malaise.

The main risk of an abnormally low white blood cell count is how susceptible it makes a person to infections. Without an adequate white blood cell response

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