What Does Phosphorus Do In The Body

What Does Phosphorus Do In The Body – If you are/have been a member of the CKD Club or a caregiver of one, like us at Team ATK, you probably know a thing or two about how the Kidney Diet is an important part of treating any Chronic Kidney Disease. be the reason. Among adjusting other nutrients, adjusting Phosphorus intake is an important part of this CKD Diet.

As mentioned in the first infographic, Phosphorus is a “structural mineral”. It is an integral part of the structure of our DNA, proteins and the “boundary walls” of every cell. Phosphorus is also important for making the “Energy Molecule” – Adenosine Triphosphate (ATP) which is essential for maintaining life. However, when we talk about Phosphorus in terms of kidney disease, our main concern is Phosphorus present in the blood stream. This part comes from absorbing Phosphorus from food in our intestines with the help of Vitamin D activated from the Kidneys.

What Does Phosphorus Do In The Body

What Does Phosphorus Do In The Body

In good health, blood phosphorus levels should be between 2.5-4.5 mg/dL. To ensure blood phosphorus levels remain within this normal range, the Recommended Dietary Allowance for Phosphorus is 800-1000 milligrams per day for a healthy person.

Phosphorus & The Ckd Diet

After being absorbed by food, when Phosphorus in the blood system is used sufficiently for the body’s functions, the kidneys filter the extra free Phosphorus from our blood. Now in any given day, the body’s various functions require the correct regulation of blood biochemistry many times over a billionth of a second. So our beautiful kidneys also remember to take care to “reabsorb” some of the filtered phosphorus back into the blood stream when and when the need arises.

When CKD begins, the specialized filtering areas within each of the million tiny filters (nephrons) in the kidney begin to scar. As a result of this, kidney maintenance of phosphorus takes a direct hit.

Initially, blood levels of Phosphorus decrease in the early stages due to excessive urine loss and lack of “reabsorption” into our bloodstream. However, surprisingly, “free” phosphorus levels rise once the kidneys enter End-Stage Renal Disease (failure).

So why is it bad? Well, you see, Mother Nature taught our body parts to be satisfied with what is needed and avoid “greed”. So if the levels of phosphorus in the blood rise above the required levels, it will not continue to strengthen our bones and teeth. Such “free” phosphorus tends to deposit in other tissues and slowly “eat” those tissues.

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To avoid such negative consequences, Parathyroid Hormone (PTH) released the Parathyroid glands located within the Thyroid Gland in the neck, and volunteered to help.

PTH literally “coaxes” our bones to “release” Calcium into the bloodstream to accompany Free Phosphorus. As a result, calcium comes from the bones to “bind” the excess “free” phosphorus and prevent the deposition of unnecessary phosphorus on other tissues. However, in the process, bones become fragile and prone to fractures. The technical name of the bone damage caused by kidney diseases is “Metabolic Bone Disease” or “Bone Mineral Disorder”. It is an inevitable problem in every CKD journey.

Therefore, the “funding” of Parathyroid Hormone (PTH) & Bones to prevent high blood levels of phosphorus in CKD ultimately does something more.

What Does Phosphorus Do In The Body

Bone Damage can’t be something you can afford, right? Therefore, as a newbie with CKD, it is important that you learn ways to control the levels of phosphorus in your blood.

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In CKD, one of the first things your medical team may advise is to adjust your diet. The technical name for this is “Medical Nutrition Therapy”. The most common term is the so-called “Kidney Diet” or simply, the CKD Diet. It is best to consult a registered Kidney Dietitian (RD) as soon as you are diagnosed with Kidney Disease. These experts specialize in the nutritional needs of kidney patients. They will guide you on all the nutritional intake allowed for kidney disease. RDs will also give you a meal plan optimized for your kidney function as seen in your blood work.

However, incorporating such meal plans into your life is not a point. If you fix one ingredient, you end up consuming more than your allowance of another restricted nutrient. In short, it’s easy to feel confused! And to think how our Kidneys even handle all the blood components perfectly 24 X 7! Well, don’t give up. Managing your CKD Diet requires some tips and tricks. Part of that is what today’s article aims to present to you.

We have described the SODIUM GUIDELINE CHART and the POTASSIUM GUIDELINE CHART before as part of helping you get started with your Kidney Diet Plan.

To help you through Phosphorus-control in your Kidney Diet (CKD), presenting here, PHOSPHORUS GUIDE GRAPHIC series. Scroll along for the right information and make a kidney-friendly lifestyle change today.

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For the latest updates from the ATK Team on All Things Kidney, bookmark this Page of our website and follow us on Instagram, Facebook, Twitter & Pinterest. In treating patients with chronic kidney disease, it is important to prevent and treat hyperphosphatemia with a combination. of food restrictions and phosphorus bonds. This post reviews the pathophysiology of hyperphosphatemia.

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The balance between food intake and phosphorus excretion can be disturbed in patients with reduced kidney function, causing hyperphosphatemia. Many patients with end-stage renal disease on dialysis require phosphate-binding drugs to control their serum phosphorus levels.

What Does Phosphorus Do In The Body

In this review, we discuss the pathophysiology of hyperphosphatemia in kidney disease, its consequences, and how to manage it, focusing on different types of phosphate binders.

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With kidney disease on the rise, psychiatrists and internists need to work together to provide better care.

Additionally, many trainees in managed care plans and accountable care organizations are now handling many of the tasks once left to professionals – including prescribing and administering phosphate binders for patients with kidney disease.

The pathophysiology of bone mineral disorders in kidney disease is complex. To simplify the discussion, we will cover it in three parts:

Phosphorus is an essential macronutrient for a wide range of cellular functions including structure, energy production, metabolism and cell signaling. It is mainly found in the form of inorganic phosphate.

Foods High In Phosphorus For Bones, Cells, And Energy

Total phosphorus balance depends on dietary phosphorus intake, intestinal absorption, kidney function and flux between extracellular and intracellular (bone) pools.

The average Western diet provides 20 mg of phosphorus per kilogram of body weight per day. Of these, 13 mg/kg is absorbed, and the rest is excreted in the feces.

Absorption of dietary phosphorus occurs mainly in the jejunum. It is mediated by a paracellular sodium-independent channel (driven by high phosphorus content within the lumina) and sodium-dependent transporters. It is also affected by nutrition and promoted by active vitamin D (1, 25 dihydroxyvitamin D

What Does Phosphorus Do In The Body

Absorbed phosphorus enters the extracellular fluid and moves in and out of the bones under the influence of parathyroid hormone.

Phosphorus: Humanity Is Flushing Away The Element

Phosphorus excretion is handled almost entirely by the kidneys. Phosphorus is freely filtered in the glomerulus and reabsorbed mainly in the proximal tubule by sodium-phosphate transporters.

Normally, when phosphorus intake is inadequate, most of the absorbed phosphorus is reabsorbed and only 10 to 20 percent is excreted in the urine. However, the threshold for phosphorus reabsorption in the proximal tubule is affected by the parathyroid hormone, FGF23, and dietary phosphorus intake: low levels of phosphorus in the serum lead to an increase in the synthesis of sodium-phosphorus cotransporters, leading to an increase (almost complete ) to be reabsorbed. and increased serum phosphorus concentration. In contrast, parathyroid hormone and FGF23 are phosphorylated and decrease the number of phosphorous transporters, which leads to an increase in the excretion of phosphorus and a decrease in the concentration of phosphorus in the serum.

FGF23 is a phosphaturic glycoprotein secreted by osteoblasts and osteocytes. It works by binding fibroblastic growth factor receptor 1 in front of its receptor, the Klotho protein.

FGF23 is regulated by serum phosphorus levels and plays a major role in the response to elevated serum phosphorus. It causes a direct increase in urinary phosphorus excretion, a decrease in intestinal phosphorus absorption (indirectly through calcitriol inhibition), and a decrease in bone mass through decreased parathyroid hormone production.

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Parathyroid hormone, in contrast, has mixed effects. It increases the renal excretion of phosphorus on the one hand but increases the excretion of phosphorus from the bone to the serum on the other hand. The latter is accomplished by increasing bone absorption (directly) and intestinal absorption (indirectly, through the stimulation of calcitriol) of phosphorus.

FGF23 inhibits parathyroid hormone and calcitriol. Parathyroid hormone stimulates FGF23 and calcitriol, whereas calcitriol inhibits parathyroid hormone. The complex interactions between these hormones are shown below.

Figure 1. Hormonal regulation of calcium and phosphorus. Serum calcium and phosphorus balance is maintained by a strong interaction between parathyroid hormone (PTH), vitamin D and fibroblast growth factor 23 (FGF23).

What Does Phosphorus Do In The Body

In chronic kidney disease, phosphorus retention can lead to secondary hyperparathyroidism, as high phosphorus levels stimulate FGF23. In the early stages of chronic kidney disease, these responses can correct phosphorus levels, but with several consequences:

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As chronic kidney disease progresses, the glomerular filtration rate decreases, the phosphorus level increases, and the above sequence of events is repeated and emphasized, which leads to

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