Low Red Blood Cell Count Normal Iron – Approximately 25% of people worldwide have anemia, a blood disorder defined by low red blood cell counts and hemoglobin concentration. Iron deficiency, the most common nutritional deficiency, is responsible for causing 50% of all anemia. Iron is essential for the human body; It performs many functions, including physical growth and neurological development, hormone synthesis, cellular function, and hemoglobin synthesis. In iron deficiency states, microcytic anemia may occur along with symptoms such as fatigue, weakness, and poor exercise tolerance. (3, 4)
As iron deficiency anemia is the most common type of anemia, it should be included in the differential diagnosis of anemia. This article will explain how iron deficiency anemia develops, the clinical manifestations, and laboratory findings that support diagnosis and an integrative approach to treatment.
- 1 Low Red Blood Cell Count Normal Iron
- 1.1 Top Lab Test To Run On Your Iron Deficiency Anemia Patients
- 1.2 What Does The Mean Corpuscular Volume (mcv) Level Test Measures?
- 2 Iron Deficiency Symptoms
- 3 Profiling Individual Human Red Blood Cells Using Common Path Diffraction Optical Tomography
Low Red Blood Cell Count Normal Iron
Iron deficiency anemia (IDA) is the most common microcytic anemia, characterized by small red blood cells (RBCs) due to a lack of hemoglobin in the body. Healthy synthesis of hemoglobin, the oxygen-carrying protein in red blood cells, requires iron. Iron deficiency progressively leads to IDA, as the body cannot sustain normal production of hemoglobin and red blood cells. (7)
Top Lab Test To Run On Your Iron Deficiency Anemia Patients
Causes of iron deficiency include blood loss, insufficient dietary intake and decreased absorption. The following groups are at increased risk of developing IDA (1):
The symptoms of iron deficiency and IDA are the same, and the severity of the symptoms is generally proportional to the degree of deficiency and anemia. A poorly oxygenated state resulting from IDA affects every system in the body, leading to many vague symptoms that can easily be attributed to other causes (1):
Iron is involved in the synthesis of thyroid hormones and hypothyroidism can result in the context of iron deficiency. Note that hypothyroidism and iron deficiency share many of the same symptoms:
A complete blood count (CBC) is a panel that includes markers that detail the size, shape, and color of red blood cells. The table below summarizes the results indicating microcytic anemia:
Iron Deficiency Anemia: Video, Anatomy & Definition
A complete iron panel includes several iron-specific blood tests. Taken together, these tests provide a comprehensive analysis of iron status and help differentiate between different types of anemia.
The reticuloendothelial system (RES), or iron recycling system, is a complex system that serves to regulate iron homeostasis in the body. If the RES is not functioning properly, even with normal serum iron and ferritin levels, the body will not be able to move iron to where it needs to go to perform its functions. In vitamin A and copper deficiency states, RES function is impaired, essentially leading to an iron deficiency state. Measuring vitamin A and copper levels can be especially useful in cases where serum iron and ferritin are normal, but symptoms of anemia are present and labs show abnormal TIBC and %Sat levels. (8, 9)
Once IDA is diagnosed, the root cause of iron deficiency needs to be identified. A thorough medical history can help with this process: a dietary recall and a complete list of medications can provide clues about lifestyle factors that contribute to low iron.
Treatment of IDA requires addressing the underlying cause of iron deficiency and, at the same time, replenishing iron stores through supplementation (4).
Complete Blood Count, Red Blood Cell Morphology
The dosage of elemental iron required to treat iron deficiency anemia in adults is 120 mg per day for at least three months. Follow-up with repeat complete blood count and iron tests is recommended after one month of treatment to confirm adequate response to treatment. Replacement therapy should be continued for one to three months after hemoglobin levels normalize to fully replenish iron stores. (5)
There are several forms of iron that you will find in oral iron supplements. The most common and affordable supplements contain iron salts, such as ferrous sulfate, but they often cause gastrointestinal disorders such as abdominal pain and constipation. Functional practitioners often recommend an alternative, better tolerated form of iron called ferrous (bis)glycinate to improve tolerance to therapy. (two)
There are now several studies that support that taking oral iron every other day is as or more effective than daily dosing in increasing serum iron levels. This dosing regimen may be more appropriate for those who do not respond to oral iron replacement as expected or who experience gastrointestinal side effects.
Intravenous (IV) iron is distributed more reliably and quickly through the circulation than oral supplementation. Intravenous infusions may be the preferred treatment for those who are intolerant to oral iron, have a gastrointestinal malabsorption disease, or do not respond to oral iron as desired. (4, 6)
Everything You Need To Know About Iron Deficiency Anemia
Blood transfusions may be necessary for severe IDA. There is no universally accepted guideline for ordering blood transfusions, but the patient’s clinical condition and symptoms are important considerations in the decision. (5)
Dietary iron has two main forms: heme and non-heme. Heme iron, found in animal sources, is very well absorbed and functional in the body. Non-heme iron, found in plant-based and iron-fortified foods, is significantly less bioavailable to the body. The main animal sources of iron include red meat, oysters, liver and chicken. Plant sources of iron include dark leafy greens, legumes, molasses and tofu. (3)
Consider supplementing vitamin A and copper to support the iron recycling system, especially when deficiencies in either nutrient are identified.
This article will not extensively describe treatment protocols for specific conditions underlying IDA. Know that addressing these conditions is necessary to treat IDA and prevent iron deficiency from recurring. Functional medicine practitioners routinely implement health problem-specific integrative protocols that include botanical herbs, nutritional supplements, dietary and lifestyle modifications, and pharmaceutical medications (when applicable).
What Does The Mean Corpuscular Volume (mcv) Level Test Measures?
Endurance athletes are at higher risk for IDA. Intense exercise increases the body’s iron needs to compensate for excess iron lost through sweat, decreases intestinal absorption secondary to acute inflammatory responses activated during exercise, and increases the destruction of red blood cells by physical forces. Some research suggests that high-intensity, resistance exercise increases iron losses by up to 70% compared to sedentary populations. Decreasing exercise intensity and frequency during active IDA therapy may improve the response to iron replacement therapy. Athletes may be candidates for an increase in dietary iron intake and supplementation to meet increased demands. (10)
Iron is an essential mineral for the human body, in part because of its involvement in the synthesis of hemoglobin and red blood cells. In iron deficiency states, microcytic anemia may occur and impaired oxygenation of the body leads to symptoms associated with iron deficiency anemia. Functional medicine professionals are trained to use a comprehensive testing strategy to understand iron status and metabolism. An integrative approach to treating iron deficiency anemia using nutritional therapy, dietary supplements, and lifestyle modifications is effective in restoring the body’s iron and red blood cell balance.
The information provided is not intended to replace professional medical advice. Always consult your doctor or other qualified healthcare professional before taking any dietary supplement or making any changes to your diet or exercise routine.
2. Christie, J. (2022b, September 13). Weakness, pale skin and headache are signs of this mineral deficiency. Rupa Saúde. https:///post/a-funcional-medicine-approach-to-iron-deficiency
Iron Deficiency Anemia: Signs And Symptoms
3. NIH. (2022, April 5). Fact sheet on iron for healthcare professionals. National Institutes of Health Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/
5. Short, MW and Domagalski, JE (2013). Iron Deficiency Anemia: Assessment and Treatment. American Family Physician, 87(2), 98–104. https://www.aafp.org/pubs/afp/issues/2013/0115/p98.html
8. Collins, J.F., Prohaska, J.R., and Knutson, M.D. (2010). Metabolic crossroads of iron and copper. Nutritional Reviews, 68(3), 133–147. https://doi.org/10.1111/j.1753-4887.2010.00271.x
9. Michelazzo, F., Oliveira, J., Stefanello, J., et al. (2013). The influence of vitamin A supplementation on iron status. Nutrients, 5(11), 4399–4413. https://doi.org/10.3390/nu5114399
Iron Deficiency Symptoms
10. NIH. (2022, June 2). Dietary supplements for exercise and athletic performance. National Institutes of Health Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/ExerciseAndAthleticPerformance-HealthProfessional/Anemia, also known as anemia, occurs when your blood has fewer than normal numbers of red blood cells or if your red blood cells do not have enough hemoglobin. Because a side effect of anemia is low oxygen circulation, symptoms of anemia often include muscle weakness, continued fatigue or lethargy, mental confusion, and sometimes mood changes.
Severe anemia or unabated anemia can sometimes also cause complications, including damage to the heart, brain and other organs, according to the National Heart, Lung, and Blood Institute (NHLBI). Although it is rare, anemia that is left untreated can even become deadly.
Considering how serious anemia is and how common it is among certain age groups — especially women of childbearing age or adults with existing health problems over the age of 65 — it’s critical that you learn to recognize the symptoms of anemia in yourself or others. your loved ones. Below you will learn about the most common signs of anemia, as well as the best ways to treat these symptoms and reduce anemia risk factors, such as iron deficiency or eating a highly processed diet.
Anemia is the condition marked by a deficiency of red blood cells or hemoglobin in the blood. Hemoglobin is an iron-rich protein that gives blood its red color. It helps cells carry oxygen from the lungs to the rest of the body.
Profiling Individual Human Red Blood Cells Using Common Path Diffraction Optical Tomography
Red blood cells contain hemoglobin. They are also important for immunity, including fighting infections, as well as blood clotting and preventing excessive bleeding.
Anemia is closely related to iron deficiency. According to the Centers for Disease Control and Prevention (CDC), iron deficiency is the most common nutritional deficiency in the world.
This is alarming considering the essential roles that iron plays, including facilitating oxygen delivery. Your body needs iron to perform many functions
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