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Best Weight Loss Over The Counter Pills – Side effects are part of the reason GlaxoSmithKline’s Alli, the first over-the-counter diet pill, works for people who take it. Richard Drew / AP

When the fat blocker Alli hit drugstore shelves last June, hopeful consumers sought the first government-approved over-the-counter weight loss drug. But it didn’t take long for the , and the lack of real weight loss for some, to convince many dieters that Alli wasn’t the only answer to their weight problems.

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In addition to Alli, there are about six prescription weight loss medications on the market. Some, like Alli, block the absorption of fat in the body. Others work in the brain to suppress appetite. But the reality is that no matter how many diet pills you take, they don’t work on their own.

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“The pills we have right now don’t seem to be terribly effective for long-term weight loss,” says registered dietitian Anne Fletcher of Mankato, Minnesota.

Still, the pharmaceutical industry and many dieters remain convinced that a pill is the answer to the nation’s growing obesity epidemic. Several new ones, including the experimental drug lorcaserin, a variation of Fen-phen. At least 30 companies are developing weight-loss drugs, and experts estimate that in the next few years there will be 10 to 15 drugs aimed at helping dieters in different ways. Pharmaceutical research firm Decision Resources projects that the market for obesity drugs in the United States will grow from $222 billion in 2006 to nearly $2 billion in 2016.

When combined with diet and exercise, obesity medications can help someone lose 5 to 10 percent more weight, research shows. But because different pills affect the body in different ways, certain people may be better suited to use one type of pill over another.

For example, a study that looked at the differences between sibutramine (Meridia) and orlistat (Xenical and Alli) found that greater weight loss with orlistat occurred in people who could be described as “conscious,” that is, their personalities were more orderly oriented or deliberate. So careful monitoring of fat intake works for them. People who have difficulty limiting their eating habits have seen a greater impact with sibutramine, which affects serotonin in the brain and makes you feel better when you eat.

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In general, the biggest mistake people make when taking diet pills is to look at them as magic bullets.

“People can’t expect a drug to do it for them,” says Gary Foster, director of the Center for Obesity Research and Education at Temple University in Philadelphia. “It’s a 50/50 partnership with the pill being half of the equation. Exercise, what we eat and our lifestyle habits … are key to long-term success.”

When clients ask to use a weight-loss drug, Fletcher, author of the book “Thin for Life,” tells them to think of it as “one leg of a four-legged stool.”

“A leg is physical activity; one is the diet; one is behavior change and the last stage can be diet pills,” she says. “Take out any of the legs that support the diet pill and the stool will fall.”

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From his research, Fletcher found that people who lost significant amounts of weight often made many attempts to lose weight before they realized long-term success.

“When we try to change any behavior, it takes most of us a few tries to get it right,” she says.

There is no real data on how safe long-term pills are, especially for young people. However, the Food and Drug Administration has only approved them for adults for up to two years of continuous use. According to an analysis of 30 trials of adults who took anti-obesity drugs for one to four years, 30 to 40 percent stopped taking them after a year, although it was unclear why.

Also, side effects are common. Sibutramine may increase blood pressure and heart rate in some patients. Orlistat, which alters the absorption of fat in food, can have embarrassing intestinal side effects. Rimonabant (used in Europe, but awaiting approval in this country) can, for some users, cause nausea, anxiety, depression and insomnia.

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However, for the obese, people with a body mass index of 30 or more, the benefits of prescription drugs may outweigh the risks, experts say.

“The most successful people are those who are willing to make a serious commitment to weight loss and willing to take responsibility for their actions and change,” says Pat Baird, a dietitian and nutrition consultant for GlaxoSmithKline’s Consumer Healthcare division, who serves as online moderator for people using Alli. She talks to 25 people a day and answers questions about weight loss, the program and the pill.

Baird admits that side effects are part of the reason Alli works for some people. When someone eats more than the prescribed 15 grams of fat per meal, they may experience not-so-pleasant digestive problems. “It helps keep people honest,” she says. When it comes to weight loss, there is no shortage of pills, drinks, and supplements that claim to help you lose weight. But do diet pills help and are they safe?

The best diet pills may contain one or more active ingredients intended to increase fat burning, decrease appetite, or reduce fat absorption.

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Not all diet pills and supplements are created equal. Some pills may cause unpleasant side effects, while others may not result in weight loss.

It is important to do your research carefully before choosing a diet pill, as some may have side effects or interact with existing conditions.

Alli is the brand name of the drug orlistat. It is one of the most popular weight loss pills.

Orlistat is available as a prescription drug and is also sold over the counter. It works by preventing the body from breaking down some of the fat that people eat. When the intestines absorb less fat, weight loss can occur.

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States that orlistat may increase weight loss by a small amount. The review found that those who took orlistat lost an average of 2.9 percent more weight than those who did not take the drug.

Orlistat may cause a change in bowel habits. People taking orlistat may experience side effects such as diarrhea, stomach pain, and difficulty controlling bowel movements.

Caffeine is a stimulant found in coffee, tea, soft drinks and chocolate. It is also often added to dietary pills and supplements.

Of 76 obese adults, those who had a high caffeine intake saw a greater reduction in fat mass, weight circumference, and overall weight compared to those who had a low caffeine intake.

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Glucomannan is a type of fiber supplement. It works by absorbing water in the gut, which causes a feeling of fullness that can lead people to eat less.

However, a more recent review of randomized controlled trials indicated that glucomannan did not appear to cause significant weight loss.

Garcinia cambogia extract contains the juices of this small fruit and is available as a diet pill. Garcinia cambogia can inhibit or prevent a fat-producing enzyme called citric acid lyase.

There is little scientific evidence to support the use of this extract to aid weight loss. agree with

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Although garcinia cambogia extract may not help with weight loss, it does not seem to cause many side effects when taken in reasonable doses. The previous report also indicated that no adverse effects occurred with a dietary dose of up to 2,800 milligrams (mg) per day.

The body produces pyruvate when it breaks down sugar. Pyruvate is also sold as a supplement to aid in weight loss, helping to break down fat and increase metabolism.

, pyruvate may have some effects on weight loss. The existing studies are weak, so the results are inconclusive.

Many diet pills contain green tea because it can increase the body’s ability to burn fat, and especially fat in the stomach area.

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Although more evidence is needed, some research indicates that drinks containing green tea extract may promote fat loss in the stomach area. Increased fat loss can also result in modest weight loss.

Conjugated linoleic acid is a type of fatty acid found primarily in beef and dairy products. It has been marketed as one of the best diet pills for its potential to increase metabolism and decrease appetite.

However, most studies of conjugated linoleic acid leading to weight loss have been done in animals. agree with

Conjugated linoleic acid appears to be safe in doses up to 6 grams per day for 12 months. Possible side effects include stomach upset, diarrhea or constipation. May not be suitable for people with diabetes.

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Hydroxycut is a popular dietary supplement. There are different Hydroxycut products, which contain various ingredients. Hydroxycut products typically contain plant extracts and caffeine, although caffeine-free versions of the supplement are also available.

There are no studies that specifically review Hydroxycut. Caffeine, which has been studied, can contribute to small amounts of weight loss.

Since the ingredients in Hydroxycut vary, it is difficult to state the possible side effects. Hydroxycut supplements that contain caffeine can cause jitteriness and an increased heart rate

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